銠(I)金屬催化烯基硼酸試劑對α,β-不飽和酮類化合物的不對稱1,4-加成反應

Abstract

本論文是利用一價銠金屬和掌性樟腦型雙環[2.2.1]雙烯配基(25A)作為催化基，催化烯基硼酸試劑與α,β-不飽和酮類化合物進行不對稱1,4加成反應，利用各種不同的烯基硼酸試劑及α,β-不飽和酮類化合物合成出一系列β-烯基取代酮化合物。這些產物都具有很好的產率以及高的立體選擇性，產率最高可達99%，而鏡像超越值可高達>99.5% ee。An efficient enantioselective conjugate addition of alkenylboronic acids to α,β-unsaturated carbonyl compounds was realized. In the presence of 1 mol% of rhodium catalyst in situ prepared from [RhCl(C2H4)2]2 and ligand 25A, conjugation addition of various alkenylboronic acids to α,β-unsaturated carbonyl compounds furnishes the desired adducts in high yields (up to 99%) and in up to >99.5% ee.