利用有機不對稱催化建構具有多取代的環己酮衍生物
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Date
2014
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Abstract
a,b-不飽和-1,3-雙酮和亞烷基丙二腈為起始物透過奎寧進行連續性的二次 Michael 加成反應，得到具有兩個立體中心的多取代環己酮衍生物，產率為 59-94%、單一非鏡像異構物和高達 92% 的鏡像超越值。
organocatalytic asymmetric double Michael addition reaction of a,b-unsaturated-1,3-diketones to 2-alkylidene malononitriles 80 has been investigated with quinine as the catalyst to afford a range of multi-substituted cyclohexanones bearing two sterecenters in good results (58-94% yield, >99:1 de, and up to 92% ee).
organocatalytic asymmetric double Michael addition reaction of a,b-unsaturated-1,3-diketones to 2-alkylidene malononitriles 80 has been investigated with quinine as the catalyst to afford a range of multi-substituted cyclohexanones bearing two sterecenters in good results (58-94% yield, >99:1 de, and up to 92% ee).
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Keywords
連續性反應, 環己酮, 鏡像選擇性, Domino reaction, Cyclohexanone, Enantioselectivity