三氯化金輔佐C-2炔醯胺呋喃化合物的分子內環化反應：吡咯衍生物的合成
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2020
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Abstract
本篇論文將探討有效率合成3,4ｰ二取代吡咯的方法。在氮氣下，以甲苯為溶劑，使用C-2帶有炔醯胺側鏈的呋喃化合物，加入催化量的三氯化金進行反應，可快速得到吡咯衍生物，此吡咯衍生物帶有順式共軛烯酮的取代基，具有進行衍生反應的潛在能力。本反應的優點為溫和的反應條件、時間短及良好的產率。
An efficient synthesis of 3,4ｰdisubstituted pyrroles is developed. Treatment of a catalytic amount of gold(III) chloride with furans tethering a ynamide at the C-2 position in toluene under nitrogen proceeds rapidly to afford pyrrole derivatives in good yields. The product possesses a (Z)-butenonyl side chain. The functionality may lead to further transformation. The advantages of this reaction are mild reaction conditions, short reaction times, and good yields.
An efficient synthesis of 3,4ｰdisubstituted pyrroles is developed. Treatment of a catalytic amount of gold(III) chloride with furans tethering a ynamide at the C-2 position in toluene under nitrogen proceeds rapidly to afford pyrrole derivatives in good yields. The product possesses a (Z)-butenonyl side chain. The functionality may lead to further transformation. The advantages of this reaction are mild reaction conditions, short reaction times, and good yields.
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路易斯酸, 三氯化金, 吡咯, 炔醯胺, 金催化, Lewis acid, gold(III) chloride, pyrrole, ynamide, gold-catalyzed