微波輔助螢光標定毛細管電泳法對安非他命狡詐家濫用藥物的分離與偵測

dc.contributor林震煌zh_TW
dc.contributorCheng-Huang Linen_US
dc.contributor.author陳冠甫zh_TW
dc.contributor.authorKuan-Fu Chenen_US
dc.date.accessioned2019-09-04T10:11:23Z
dc.date.available2018-6-19
dc.date.available2019-09-04T10:11:23Z
dc.date.issued2013
dc.description.abstract本研究利用微波輔助螢光標定應用於毛細管電泳分析方法,用來分析鄰、間、對-氯安非他命和鄰、間、對-氟安非他命這六種安非他命濫用藥物與 2,5-dimethoxy- 4-ethylthio-phenethylamine(2C-T-2)、2,5-dimethoxy-4-(n)-propylthiophen- ethylamine(2C-T-7)、4-chloro-2,5- dimethoxyphenethylamine(2C-C)、4-bromo-2,5-dimethoxy-phenethylamine(2C-B)及 2,5-dimethoxy-4-iodo- phenethylamine(2C-I)五種 2C 系列的苯乙胺類毒品。利用 FITC(fluorescein isothiocyanate isomer I)當作螢光標記並使用藍光雷射(473 nm)作激發光源進行偵測。在過去使用 FITC 作衍生劑的衍生時間至少需要 20 小時,現今使用微波輔助衍生所需時間約 5 分鐘即可完成。zh_TW
dc.description.abstractA microwave-assisted fluorescence labeling method for use in CE-LIF (capillary electrophoresis-laser induced fluorescence) is described. Six amphetamine-like designer drugs, namely, o-, m-, p-chloro- and o-, m-, p-fluoro-amphetamine derivatives, and five 2C-series of phenethylamine designer drugs, including 2,5-dimethoxy-4-ethylthio-phenethylamine (2C-T-2), 2,5-dimethoxy-4-(n)-propylthiophenethylamine(2C-T-7), 4-chloro-2,5-dimethoxy-phenethylamine(2C-C), 4-bromo-2,5-dimethoxy- phenethylamine(2C-B), 2,5-dimethoxy-4-iodo-phenethylamine(2C-I) derivatives, were synthesized and used as model compounds. FITC (fluoresceinisothiocyanate isomer I) and a blue-laser were used as the fluorescent labeling reagent and excitation source, respectively. When a microwave oven was used, the reaction was complete within ~ 5 min,while the classical method required at least 20 h(usually, an overnight reaction)en_US
dc.description.sponsorship化學系zh_TW
dc.identifierGN0699420326
dc.identifier.urihttp://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22GN0699420326%22.&%22.id.&
dc.identifier.urihttp://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/100932
dc.language中文
dc.subject毛細管電泳zh_TW
dc.subject微波衍生zh_TW
dc.subject安非他命濫用藥物zh_TW
dc.subject苯乙胺類zh_TW
dc.subjectFITCzh_TW
dc.subjectCE-LIFen_US
dc.subjectmicrowave-assisteden_US
dc.subjectamphetamine-like designer drugsen_US
dc.subjectphenethylamine designer drugsen_US
dc.title微波輔助螢光標定毛細管電泳法對安非他命狡詐家濫用藥物的分離與偵測zh_TW
dc.titleA microwave-assisted fluorescent labeling method for the separation and detection of amphetamine-like designer drugs by capillary electrophoresis.en_US

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
n069942032601.pdf
Size:
1.86 MB
Format:
Adobe Portable Document Format

Collections