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Title: A Triantennary Dendritic Galactoside-Capped Nanohybrid with a ZnS/CdSe Nanoparticle Core as a Hydrophilic, Fluorescent, Multivalent Probe for Metastatic Lung Cancer Cells
Authors: 國立臺灣師範大學化學系
C.-T. Chen
Y.-S. Munot
S.-B. Salunke
Y.-C. Wang
R.-K. Lin
C.-C. Lin
Chia-Chun Chen
Y-H. Liu
Issue Date: 22-Feb-2008
Publisher: Wiley-VCH Verlag
Abstract: A new tri-antennary, galactoside-capped gallamide dendritic anchor with thiolate focal group is synthesized via click chemistry. The highly hydrophilic dendron was efficiently anchored onto the surface of CdSe/ZnS core/shell nanoparticles in a covalent fashion, as evidenced by 1H NMR spectrum of the resultant nanohybrid with intact core fluorescent property. The water-soluble nano-hybrid was found smoothly and selectively uptaken by lung cancer cells enriched with membrane-bound asialoprotein receptors in 2–3 h, as evidenced by confocal microscopic analysis. Furthermore, cancer cells that are undergoing active mitosis also tend to uptake the nanohybrids efficiently and remain sustainable in serum-containing medium for several days, which shed light on its application as a photodynamic drug carrier for apoptosis study.
ISSN: 1616-301X
Other Identifiers: ntnulib_tp_C0301_01_048
Appears in Collections:教師著作

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