A Triantennary Dendritic Galactoside-Capped Nanohybrid with a ZnS/CdSe Nanoparticle Core as a Hydrophilic, Fluorescent, Multivalent Probe for Metastatic Lung Cancer Cells

dc.contributor 國立臺灣師範大學化學系 zh_tw
dc.contributor.author C.-T. Chen en_US
dc.contributor.author Y.-S. Munot en_US
dc.contributor.author S.-B. Salunke en_US
dc.contributor.author Y.-C. Wang en_US
dc.contributor.author R.-K. Lin en_US
dc.contributor.author C.-C. Lin en_US
dc.contributor.author Chia-Chun Chen en_US
dc.contributor.author Y-H. Liu en_US
dc.date.accessioned 2014-12-02T06:41:34Z
dc.date.available 2014-12-02T06:41:34Z
dc.date.issued 2008-02-22 zh_TW
dc.description.abstract A new tri-antennary, galactoside-capped gallamide dendritic anchor with thiolate focal group is synthesized via click chemistry. The highly hydrophilic dendron was efficiently anchored onto the surface of CdSe/ZnS core/shell nanoparticles in a covalent fashion, as evidenced by 1H NMR spectrum of the resultant nanohybrid with intact core fluorescent property. The water-soluble nano-hybrid was found smoothly and selectively uptaken by lung cancer cells enriched with membrane-bound asialoprotein receptors in 2–3 h, as evidenced by confocal microscopic analysis. Furthermore, cancer cells that are undergoing active mitosis also tend to uptake the nanohybrids efficiently and remain sustainable in serum-containing medium for several days, which shed light on its application as a photodynamic drug carrier for apoptosis study. en_US
dc.description.uri http://onlinelibrary.wiley.com/doi/10.1002/adfm.200700449/pdf zh_TW
dc.identifier ntnulib_tp_C0301_01_048 zh_TW
dc.identifier.issn 1616-301X zh_TW
dc.identifier.uri http://rportal.lib.ntnu.edu.tw/handle/20.500.12235/42332
dc.language en_US zh_TW
dc.publisher Wiley-VCH Verlag en_US
dc.relation Advanced Functional Materials, 18(4), 527-540. en_US
dc.relation.uri http://dx.doi.org/10.1002/adfm.200700449 zh_TW
dc.subject.other Receptor-mediated en_US
dc.subject.other Endocytotic en_US
dc.subject.other Triantemmary-galactose nanohybrids en_US
dc.subject.other Click chemistry en_US
dc.subject.other Multivalency binding en_US
dc.title A Triantennary Dendritic Galactoside-Capped Nanohybrid with a ZnS/CdSe Nanoparticle Core as a Hydrophilic, Fluorescent, Multivalent Probe for Metastatic Lung Cancer Cells en_US
Files
Collections