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Title: Selective Binding of Mannose-Encapsulated Gold Nanoparticles to Type I Pili in Escherichia Coli
Authors: 國立臺灣師範大學化學系
C.-C. Lin
Y.-C. Yeh
C.-Y. Yang
C.-L. Chen
G.-F. Chen
Chia-Chun Chen
Y.-C. Wu
Issue Date: 10-Apr-2002
Publisher: American Chemical Society
Abstract: The synthesis, characterization and biological application of mannose encapsulated gold nanoparticles (m-AuNP) are reported. m-AuNP is well dispersed and very stable without aggregation in the media of broad ion strength and pH ranges. The selective binding of m-AuNP to the mannose adhesin FimH of bacterial type 1 pili is demonstrated using transmission electron microscopy. The competition assay with free mannose suggests that m-AuNP binds FimH better than free mannose does. This work demonstrates that carbohydrate attached nanoparticles can be used as an efficient affinity label and a multi-ligand carrier in a biological system.
ISSN: 0002-7863
Other Identifiers: ntnulib_tp_C0301_01_010
Appears in Collections:教師著作

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