二氧化矽催化吲哚烯丙基化之Friedel-Crafts反應
| dc.contributor | 陳焜銘 | zh_TW |
| dc.contributor.author | 何青胤 | zh_TW |
| dc.date.accessioned | 2019-09-04T10:08:25Z | |
| dc.date.available | 2013-06-30 | |
| dc.date.available | 2019-09-04T10:08:25Z | |
| dc.date.issued | 2011 | |
| dc.description.abstract | 本論文旨在探討以二氧化矽及有機催化劑催化Friedel-Crafts反應合成吲哚之烯丙基化產物。近年來發現許多天然物分子含有吲哚之分子結構，因具有生物活性，可應用於藥物分子的合成。我們以二氧化矽催化引朵與allylic acetate 40進行Friedel-Crafts反應，得到高產率的引朵烯丙基化產物，且大量製備仍然可以保持77%的產率；也嘗試使用有機催化劑催化其反應，眾多篩選反應後，發現以20 mol%的催化劑55，在二氯甲烷為溶劑下，可得到最佳產率9%及鏡像超越值20% ee，結果並不理想。後續研究在進行中，期望能夠找到合適的催化劑或者修飾起始物的官能基，使既有之催化劑能夠與起始物有更好的反應，改善產率及鏡像超越值。 | zh_TW |
| dc.description.abstract | This dissertation focus on the use of silica-gel and organocatalyst to catalyze the Friedel-Crafts reaction of indole with allylic acetate 40. In recent years, indole derivatives has been found in many natural products, and their already used in a lot of pharmaceuticals because of their biological activities. In our lab we found that useing silica-gel as medium can get a high yield of indole allylation product, even if in large scale we can get 77% yield. We also use amounts of organocatalysts try to get some enantioselectivities, but the best result we can get only 9% yield and 20% ee when use 20mol % organocatalyst 55. In the future, we will continue this article, to get a high yield and high enantioselectivity is our objective, we will try to modify the substrate make it easier to interact with the catalyst, or to find some new catalysts. | en_US |
| dc.description.sponsorship | 化學系 | zh_TW |
| dc.identifier | GN0698420898 | |
| dc.identifier.uri | http://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22GN0698420898%22.&%22.id.& | |
| dc.identifier.uri | http://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/100910 | |
| dc.language | 中文 | |
| dc.subject | 吲哚 | zh_TW |
| dc.subject | indole | en_US |
| dc.title | 二氧化矽催化吲哚烯丙基化之Friedel-Crafts反應 | zh_TW |