銠金屬(I)結合掌性雙環[2.2.1]雙烯配體進行不對稱加成催化反應：合成掌性α-及β2-胺基酸及其衍生化合物之應用
| dc.contributor | 吳學亮 | zh_TW |
| dc.contributor | Wu, Hsyueh-Liang | en_US |
| dc.contributor.author | 簡嘉宏 | zh_TW |
| dc.contributor.author | Jian, Jia-Hong | en_US |
| dc.date.accessioned | 2020-10-19T06:51:31Z | |
| dc.date.available | 2025-01-05 | |
| dc.date.available | 2020-10-19T06:51:31Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | 本論文利用銠金屬催化試劑針對去氫丙胺酸107、113或β取代硝基烯酸酯128進行一系列不對稱加成反應，可以得到具有高產率與良好鏡像超越值之加成產物。並且透過同位素實驗以及DFT理論計算推測其催化反應路徑中的配基效應、質子化步驟和立體效應。此方法能夠有效合成出掌性α-或β2-胺基酸及其衍生物。 | zh_TW |
| dc.description.abstract | A highly enantioselective rhodium-catalyzed conjugate addition reactions of dehydroalanines 107, 113 and β-nitroacrylates 128 with a variety of aryl boronic acids is described, providing an access to both chiral α- and β2-amino acid derivatives in good yields and enantioselectivities. Mechanistic studies which include deuterium labelling experiments and DFT calculations supported the ligand-assisted, protonation step and the stereochemical effect of mechanism. Thses method were applied for the synthesis of α-and β2-amino acid derivatives. | en_US |
| dc.description.sponsorship | 化學系 | zh_TW |
| dc.identifier | G080442009S | |
| dc.identifier.uri | http://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22G080442009S%22.&%22.id.& | |
| dc.identifier.uri | http://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/111191 | |
| dc.language | 中文 | |
| dc.subject | 銠金屬催化試劑 | zh_TW |
| dc.subject | 胺基酸 | zh_TW |
| dc.subject | 加成反應 | zh_TW |
| dc.subject | rhodium-catalyzed | en_US |
| dc.subject | amino acid | en_US |
| dc.subject | conjugate addition | en_US |
| dc.title | 銠金屬(I)結合掌性雙環[2.2.1]雙烯配體進行不對稱加成催化反應：合成掌性α-及β2-胺基酸及其衍生化合物之應用 | zh_TW |
| dc.title | Enantioselective Synthesis of α- and β2- Amino Acids via Rhodium Catalyzed Asymmetric Transformations | en_US |