銠金屬 (I) / 掌性雙烯配體催化芳香硼酸與α-二酮之不對稱1,2-加成反應
| dc.contributor | 吳學亮 | zh_TW |
| dc.contributor | Wu, Hsyueh-Liang | en_US |
| dc.contributor.author | 周孟義 | zh_TW |
| dc.contributor.author | Zhou, Meng-Yi | en_US |
| dc.date.accessioned | 2019-09-04T09:06:11Z | |
| dc.date.available | 不公開 | |
| dc.date.available | 2019-09-04T09:06:11Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | 本論文探討利用一價銠金屬以及本實驗室所開發的掌性雙環[2.2.1]雙烯配基41B所形成的錯合物，在甲苯溶劑中，並以水當共溶劑，1,4-二氮雜二環[2.2.2]辛烷(DABCO)當作鹼，於60 °C下，催化一系列芳香硼酸2與α-二酮1進行不對稱1,2-加成反應。在3 mol%的銠金屬和掌性雙烯配體41B形成之催化劑反應下，建構出含掌性四級α-羥基酮化合物的加成產物3，得到3%到90%的產率，以及20%到77%的鏡像超越值。 | zh_TW |
| dc.description.abstract | Using 3 mol% of the chiral bicyclo[2.2.1]heptadiene ligand in the Rh(I)-catalyzed enantioselective 1,2-addition of a variety of arylboronic acids 2 to α-diketones 1, with DABCO as the base in the toluene‐water binary solvent system at 60 °C. Afforded the corresponding adducts, α-hydroxyketones 3 bearing a quaternary carbon stereogenic center in 3 – 90% yield and 20 – 77% ee. | en_US |
| dc.description.sponsorship | 化學系 | zh_TW |
| dc.identifier | G060242078S | |
| dc.identifier.uri | http://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22G060242078S%22.&%22.id.& | |
| dc.identifier.uri | http://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/100002 | |
| dc.language | 中文 | |
| dc.subject | 1 | zh_TW |
| dc.subject | 2-加成反應 | zh_TW |
| dc.subject | 1 | en_US |
| dc.subject | 2-addition | en_US |
| dc.title | 銠金屬 (I) / 掌性雙烯配體催化芳香硼酸與α-二酮之不對稱1,2-加成反應 | zh_TW |
| dc.title | Enantioselective 1,2-Addition of Aryl Boronic acids to α-Diketones using Rh/diene Complexes | en_US |