經由[3+3]硫尿素有機催化下合成非鏡像選擇性之螺環茚吡喃併吡唑化合物
| dc.contributor | 陳焜銘 | zh_TW |
| dc.contributor | Chen, Kwunmin | en_US |
| dc.contributor.author | 黃千益 | zh_TW |
| dc.contributor.author | Huang, Chien-Yi | en_US |
| dc.date.accessioned | 2019-09-04T09:12:08Z | |
| dc.date.available | 不公開 | |
| dc.date.available | 2019-09-04T09:12:08Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | 本實驗室藉由兩個有機小分子進行有機連鎖反應，發展出高非鏡像選擇之螺環茚吡喃併吡唑化合物。使用吡唑酮與四取代烯烴，利用 20 mol %的硫尿素衍生之有機催化劑及20 mol %的 4-二甲氨基吡啶，經由[3+3]合環反應，Michael/Acetalization 反應，生成多官能基的螺環茚吡喃併吡唑化合物，其具有不錯的產率（高達 94 %）及優異的非鏡像選擇性（高達> 20:1 dr）。此外，也經由單晶繞射 X-ray 確認其產物相對立體組態。而螺環茚吡喃并吡唑化合物尚未有相關文獻報導，期許此方法能應用於天然物之合成上。 | zh_TW |
| dc.description.abstract | An organocascade reaction between pyrazolone and arylallylilidene-indene-1,3-diones derivated tertiary substituted alkene has been developed to a [3+3]-cycloaddtion leading functionalized dihydrospiro[indene-2,4'-pyrano[2,3-c]pyrazole]-1,3-dione frameworks. The reaction mediated by thiourea derived organocatalyst proceeds via Michael/Acetalization reaction in high yields and with excellent diasteroslectivity (up to >20:1dr). The relatived configuration of the cyclized product was determined by the single crystal X-ray analysis | en_US |
| dc.description.sponsorship | 化學系 | zh_TW |
| dc.identifier | G060542051S | |
| dc.identifier.uri | http://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22G060542051S%22.&%22.id.& | |
| dc.identifier.uri | http://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/100202 | |
| dc.language | 中文 | |
| dc.subject | 有機連鎖反應 | zh_TW |
| dc.subject | [3+3]加成反應 | zh_TW |
| dc.subject | 螺環化合物 | zh_TW |
| dc.subject | Organocascade | en_US |
| dc.subject | Spirocompound | en_US |
| dc.subject | [3+3]-Annulation | en_US |
| dc.subject | Diasteroselcetivity | en_US |
| dc.title | 經由[3+3]硫尿素有機催化下合成非鏡像選擇性之螺環茚吡喃併吡唑化合物 | zh_TW |
| dc.title | Diastereoselective Synthesis of Dihydrospiro[indene-2,4’-pyrano[2,3-c]pyrazole]-1,3-dione Scaffolds via [3+3] Thiourea-Catalyzed Annulation | en_US |