三氯化銦輔佐側鏈共軛苯乙烯炔－炔醯胺衍生物的分子內環化反應: δ－內醯胺化合物的合成
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2020
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Abstract
利用三氯化銦催化劑，可有效的將側鏈共軛苯乙烯炔－炔醯胺起始物，進行分子內環化反應合成出δ-內醯胺。起始物容易製備且合環過程中，不需要添加額外的氧化劑（N－氧化物，亞碸或環氧化物）。此反應僅需3.3當量的InCl3在溫度40 ℃下及短反應時間的條件下即能得到含共軛苯乙烯的δ－內醯胺骨架。
關鍵字：三氯化銦、δ－內醯胺、分子內環化反應
Indium（III） chloride enabled the efficient synthesis of δ-lactams via intramolecular cyclization of ynamido-tethered conjugated styryl-ynes. In this process, formation of the δ-lactams from easily available ynamido-tethered conjugated styryl-ynes does not requiring an additional oxidant (N-oxides, sulfoxides, or epoxides). The reaction requires only 3.3 equivalent InCl3 at 40 ℃ in minutes under mild reaction conditions to afford δ-lactams. Keywords: Indium(III) chloride、δ-lactams、intramolecular cyclization.
Indium（III） chloride enabled the efficient synthesis of δ-lactams via intramolecular cyclization of ynamido-tethered conjugated styryl-ynes. In this process, formation of the δ-lactams from easily available ynamido-tethered conjugated styryl-ynes does not requiring an additional oxidant (N-oxides, sulfoxides, or epoxides). The reaction requires only 3.3 equivalent InCl3 at 40 ℃ in minutes under mild reaction conditions to afford δ-lactams. Keywords: Indium(III) chloride、δ-lactams、intramolecular cyclization.
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三氯化銦, δ－內醯胺, 分子內環化反應, Indium(III) chloride, δ-lactams, intramolecular cyclization