2,4一二氨基－6－取代嘧啶哌嗪之合成
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Date
1984-06-??
Authors
許春峰
陳朝棟
洪志明
王澄霞
Journal Title
Journal ISSN
Volume Title
Publisher
國立臺灣師範大學研究發展處
Office of Research and Development
Office of Research and Development
Abstract
滅殺除癌（Methotrexate, MTX）是一種於癌症化學療法中被廣泛使用的藥物。2.4一二氨基－6－取代嘧啶哌嗪（6）可作為合成MTX的起始反應物。本研究分別從嘧啶衍生物（Pyrimidine derivatives）及派嗪 衍生物（Pyrazine derivatives）合成化合物（6）。
Methotrexate (MTX) is an important anticancer drug widely used in cancer chemotherapy. 2,4-Diamino-6-substitued pteridine (6) is the intermediate for MTX. In this research the intermediate (6) was synthesized from a pyrimidine deri-vative and also from a pyrazire derivative.
Methotrexate (MTX) is an important anticancer drug widely used in cancer chemotherapy. 2,4-Diamino-6-substitued pteridine (6) is the intermediate for MTX. In this research the intermediate (6) was synthesized from a pyrimidine deri-vative and also from a pyrazire derivative.