2,4一二氨基-6-取代嘧啶哌嗪之合成

dc.contributor.author許春峰zh_tw
dc.contributor.author陳朝棟zh_tw
dc.contributor.author洪志明zh_tw
dc.contributor.author王澄霞zh_tw
dc.date.accessioned2014-10-27T15:25:34Z
dc.date.available2014-10-27T15:25:34Z
dc.date.issued1984-06-??zh_TW
dc.description.abstract滅殺除癌(Methotrexate, MTX)是一種於癌症化學療法中被廣泛使用的藥物。2.4一二氨基-6-取代嘧啶哌嗪(6)可作為合成MTX的起始反應物。本研究分別從嘧啶衍生物(Pyrimidine derivatives)及派嗪 衍生物(Pyrazine derivatives)合成化合物(6)。zh_tw
dc.description.abstractMethotrexate (MTX) is an important anticancer drug widely used in cancer chemotherapy. 2,4-Diamino-6-substitued pteridine (6) is the intermediate for MTX. In this research the intermediate (6) was synthesized from a pyrimidine deri-vative and also from a pyrazire derivative.en_US
dc.identifierAE71E78F-268F-65C4-C6EA-E32830B7F181zh_TW
dc.identifier.urihttp://rportal.lib.ntnu.edu.tw/handle/20.500.12235/17540
dc.language中文zh_TW
dc.publisher國立臺灣師範大學研究發展處zh_tw
dc.publisherOffice of Research and Developmenten_US
dc.relation(29),631-643zh_TW
dc.relation.ispartof師大學報zh_tw
dc.subject.other一二氨基zh_tw
dc.subject.other合成zh_tw
dc.subject.other嘧啶哌嗪zh_tw
dc.title2,4一二氨基-6-取代嘧啶哌嗪之合成zh-tw
dc.title.alternativeSynthesis of 2,4-Diamino-6-Substitujed Pteridinezh_tw

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