2,4一二氨基-6-取代嘧啶哌嗪之合成
dc.contributor.author | 許春峰 | zh_tw |
dc.contributor.author | 陳朝棟 | zh_tw |
dc.contributor.author | 洪志明 | zh_tw |
dc.contributor.author | 王澄霞 | zh_tw |
dc.date.accessioned | 2014-10-27T15:25:34Z | |
dc.date.available | 2014-10-27T15:25:34Z | |
dc.date.issued | 1984-06-?? | zh_TW |
dc.description.abstract | 滅殺除癌(Methotrexate, MTX)是一種於癌症化學療法中被廣泛使用的藥物。2.4一二氨基-6-取代嘧啶哌嗪(6)可作為合成MTX的起始反應物。本研究分別從嘧啶衍生物(Pyrimidine derivatives)及派嗪 衍生物(Pyrazine derivatives)合成化合物(6)。 | zh_tw |
dc.description.abstract | Methotrexate (MTX) is an important anticancer drug widely used in cancer chemotherapy. 2,4-Diamino-6-substitued pteridine (6) is the intermediate for MTX. In this research the intermediate (6) was synthesized from a pyrimidine deri-vative and also from a pyrazire derivative. | en_US |
dc.identifier | AE71E78F-268F-65C4-C6EA-E32830B7F181 | zh_TW |
dc.identifier.uri | http://rportal.lib.ntnu.edu.tw/handle/20.500.12235/17540 | |
dc.language | 中文 | zh_TW |
dc.publisher | 國立臺灣師範大學研究發展處 | zh_tw |
dc.publisher | Office of Research and Development | en_US |
dc.relation | (29),631-643 | zh_TW |
dc.relation.ispartof | 師大學報 | zh_tw |
dc.subject.other | 一二氨基 | zh_tw |
dc.subject.other | 合成 | zh_tw |
dc.subject.other | 嘧啶哌嗪 | zh_tw |
dc.title | 2,4一二氨基-6-取代嘧啶哌嗪之合成 | zh-tw |
dc.title.alternative | Synthesis of 2,4-Diamino-6-Substitujed Pteridine | zh_tw |
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