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Title: 2,4一二氨基-6-取代嘧啶哌嗪之合成
Other Titles: Synthesis of 2,4-Diamino-6-Substitujed Pteridine
Authors: 許春峰
Issue Date: Jun-1984
Publisher: 國立臺灣師範大學研究發展處
Office of Research and Development
Abstract: 滅殺除癌(Methotrexate, MTX)是一種於癌症化學療法中被廣泛使用的藥物。2.4一二氨基-6-取代嘧啶哌嗪(6)可作為合成MTX的起始反應物。本研究分別從嘧啶衍生物(Pyrimidine derivatives)及派嗪 衍生物(Pyrazine derivatives)合成化合物(6)。
Methotrexate (MTX) is an important anticancer drug widely used in cancer chemotherapy. 2,4-Diamino-6-substitued pteridine (6) is the intermediate for MTX. In this research the intermediate (6) was synthesized from a pyrimidine deri-vative and also from a pyrazire derivative.
Other Identifiers: AE71E78F-268F-65C4-C6EA-E32830B7F181
Appears in Collections:師大學報

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