2-碘苯胺衍生物和丙炔基二酮類/1-苯基-2-甲苯磺乙酮化合物經由銅催化分子內雙環化氧化級聯反應獲得3-羥基-3-呋喃基異茚二酮衍生物

Abstract

論文描述了3-羥基-3-呋喃基異吲哚啉酮衍生物的合成。本論文的內容分為兩章。第一章介紹了關於3-羥基異吲哚啉酮衍生物的藥用重要性和材料重要性的文獻綜述，以及構建3-羥基異吲哚啉酮衍生物的合成方法。第二部分說明了通過銅催化串聯雙環化從炔丙基二羰基化合物和2-碘苯甲酰胺衍生物生成3-羥基-3-呋喃基異吲哚啉酮衍生物的一鍋兩步法。此外，該方法通過探索2-炔基-2-苯磺醯基苯丙酮取代炔基二酮化合物得到3-羥基-2-苯基-3-(5-苯基-4-甲磺醯基)異吲哚啉酮衍生品。該方法相對較快、簡單、方便，可得到範圍廣泛的3-羥基-3-呋喃基異茚二酮衍生物。

The thesis describes about the synthesis of 3-hydroxy-3-furylisoindolinone derivatives. The contents of this thesis are divided into two chapter. The first chapter describes about the literature review on about medicinal importance and material importance of 3-hydroxyisoindolinone derivatives also synthetic procedures for construction of 3-hydroxyisoindolinone derivatives. Further, the present chapter concludes with the aim of the thesis.The second part illustrates one-pot two-step method for the generation of 3-hydroxy-3-furylisoindolinone derivatives from propargyldicarbonyl compounds and 2-Iodobenzamide derivatives via copper catalyzed tandem double cyclization. Further, the methodology was extended by exploring the 2-proparyl-2-phenylsulfonyl-acetophenone by replacing propargyldicarbonyl compounds to obtain 3-hydroxy-2-phenyl-3-(5-phenyl-4-tosylfuran-2-yl)isoindolin-1-one derivatives. This method is relatively faster, simple and convenient to obtain a wide range of 3-hydroxy-3-furyl isoindenedione derivatives.