經由Sulfa-Michael/Amino-cyclization/Acetalization非鏡像選擇性合成外消旋呋喃[2,3-e][1,4]噻嗪酮架構

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dc.contributor陳焜銘zh_TW
dc.contributorChen, Kwun-Minen_US
dc.contributor.author黃正維zh_TW
dc.contributor.authorHuang, Jheng-Weien_US
dc.date.accessioned2019-09-04T09:13:18Z
dc.date.available2018-07-27
dc.date.available2019-09-04T09:13:18Z
dc.date.issued2018
dc.description.abstract中文摘要 本文利用有機分子進行有機反應，發展具有高非鏡像選擇性之官能基的呋喃噻嗪酮結構。本實驗利用1,3-茚滿二酮 (三氟甲基)與2-胺基苯硫酚為起始物，在沒有催化劑的條件下，進行Sulfa-Michael/amino-cyclization/acetalization反應，得到多取代的呋喃[2,3,e][1,4]噻嗪酮結構，並同時建立三個四級碳及四個立體中心，具有傑出的產率(高達95%)及優異的非鏡像選擇性(高達 >20:1)。此外，也經由單晶繞射X-ray確認其產物的相對立體組態；也期許本實驗可應用在天然物合成及相關生物應用方面。zh_TW
dc.description.abstractAbstract In this thesis, organic molecules were used for organic reactions to develop furothiazinone structures with diastereoselective functionalized groups. In this experiment, Sulfa-Michael/amino-cyclization/acetalization reaction was performed by using 1,3-indanedione (trifluoromethyl) and 2-aminothiophenol as the initial starting materials in the absence of a catalyst. Multi-substituted furo[2,3,e][1,4]thiazinone structure, and the simultaneous establishment of three quaternary carbons and four stereocenters, with excellent yields (up to 95%) and diastereoselectivities (up to >20:1). In addition, the corresponding relative three-dimensional configuration of the product was also confirmed via single crystal diffraction X-ray; it is also expected that this experiment can be applied in the synthesis of natural products and related biological applications.en_US
dc.description.sponsorship化學系zh_TW
dc.identifierG060542092S
dc.identifier.urihttp://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22G060542092S%22.&%22.id.&
dc.identifier.urihttp://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/100231
dc.language中文
dc.subject硫麥克加成反應zh_TW
dc.subject胺環化反應zh_TW
dc.subject縮醛反應zh_TW
dc.subject呋喃噻嗪酮zh_TW
dc.subjectSulfa-Michael additionen_US
dc.subjectamino-cyclizationen_US
dc.subjectacetalizationen_US
dc.subjectfurothiazinoneen_US
dc.title經由Sulfa-Michael/Amino-cyclization/Acetalization非鏡像選擇性合成外消旋呋喃[2,3-e][1,4]噻嗪酮架構zh_TW
dc.titleDiastereoselective Synthesis of (±)-Furo[2,3-e][1,4] thiazinone scaffold via Sulfa-Michael/Amino-cyclization / acetalizationen_US

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