三氯化鐵輔佐環形-2-烯-7-炔-8-苯酮、醇分子內環化反應—螺旋[4,5]癸烷衍生物的合成
| dc.contributor | 葉名倉 | zh_TW |
| dc.contributor | Ming-Chang P. Yeh | en_US |
| dc.contributor.author | 林欣慧 | zh_TW |
| dc.contributor.author | Hsin-Hui Lin | en_US |
| dc.date.accessioned | 2019-09-04T10:04:53Z | |
| dc.date.available | 2016-7-12 | |
| dc.date.available | 2019-09-04T10:04:53Z | |
| dc.date.issued | 2011 | |
| dc.description.abstract | 本文分為兩部分： 利用1.5當量的三氯化鐵與8-芳香基- 2-烯-7-炔- 1-酮在於1,2-二溴乙烷溶液中在45 ℃下反應 2至16小時，可以得到(E)-螺旋[4,5]癸酮衍生物，產率約20 ~ 55%。 三氯化鐵同時也是很好的路易士酸，可以使帶有炔基之烯醇化合物行合環反應得到(E)-螺旋[4,5]癸烯衍生物系統。將三氯化鐵與8-芳香基- 2-烯-7-炔- 1-醇在室溫條件下、二氯甲烷溶液中反應，優點是反應時間少於三分鐘且有不錯的產率。 | zh_TW |
| dc.description.abstract | Reaction of cyclic 8-aryl-2-en-7-yn-1-ones with iron(III) chloride affording (E)-spiro[4,5]decanone derivatives was developed. Treatment of 1.5 eq of FeCl3 with cyclic 8-aryl-2-en-7-yn-1-ones in 1,2-dibromoethane at 45 ℃ for 2-16 hours produced (E)-spiro[5,4] decanone derivatives in 20-50 %. Iron(III) chloride was also an excellent Lewis acid to promote the synthesis of (E)-spiro[4,5]decene systems from cyclic 8-aryl-2-en-7-yn-1-ols. The reaction occurred in less than 3 minutes at room temperture in methylene chloride solution and in good yields. | en_US |
| dc.description.sponsorship | 化學系 | zh_TW |
| dc.identifier | GN0698420460 | |
| dc.identifier.uri | http://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22GN0698420460%22.&%22.id.& | |
| dc.identifier.uri | http://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/100875 | |
| dc.language | 中文 | |
| dc.subject | 螺旋化合物 | zh_TW |
| dc.subject | 螺旋[4 | zh_TW |
| dc.subject | 5]癸烷 | zh_TW |
| dc.subject | spiro compound | en_US |
| dc.subject | spiro[4 | en_US |
| dc.subject | 5]decanone | en_US |
| dc.title | 三氯化鐵輔佐環形-2-烯-7-炔-8-苯酮、醇分子內環化反應—螺旋[4,5]癸烷衍生物的合成 | zh_TW |
| dc.title | Cyclization of cyclic 8-aryl-2,7-enyn-1-ones and cyclic 8-aryl-2,7-enyn-1-ols with FeCl3 –the synthesis of spiro[4,5]decane derivatives | en_US |