鐵(III)/過氧化物催化系統氧化芳香族烯烴類之研究

Abstract

氧化烯烴斷鍵是有機合成的一個重要步驟。本研究選用與環境相容性高的鐵（III)鹽作為催化劑，2,9-二甲基-1,10-菲羅啉作為配位基及過氧化叔丁醇作為氧化劑，在常溫常壓下進行氧化反應，其中雙取代的芳基（1,1-)烯烴起始物產率較高。此外，配位基2,9-二甲基-1,10-菲羅啉對單取代與雙取代的芳基（1,1-)烯烴類化合物的反應性影響不盡相同。本論文提供一個操作簡單且遵循綠色化學反應條件的催化系統，可望能應用於大規模合成上。Oxidative alkene cleavage is an important reaction in organic synthesis. The environmentally compatible iron（III） salt was chosen as catalyst in this research. Catalyzed aryl alkenes oxidation by TBHP and neocuproine as ligand at ambient temperature. The di-substituted （1,1-）aryl alkenes achieved better yield. In addition, the reactivity to mono- and di-substituted aryl alkenes were quite different for reactions with and without ligand. We provide an easy-to-operate and green-chemistry-conforming method which is good for large-scale synthesis application.