以銅(I)金屬試劑催化級聯環化反應合成5,13-二氫-11H-喹唑啉基[2,3-b]喹唑啉-11-酮及其衍生物

Abstract

本篇論文闡述如何利用銅金屬試劑催化合成5,13-二氫-11H-喹唑啉基[2,3-b]喹唑啉-11-酮及其衍生物。內容主要可分為兩個部分，第一部分包含與銅金屬試劑催化相關的級聯環化反應之文獻回顧與研究動機。第二部分描述以2-碘-N-(2-碘芐基)苯甲醯胺與氰胺在銅試劑的催化下合成5,13-二氫-11H-喹唑啉基[2,3-b]喹唑啉-11-酮及其衍生物的方法學發展。其廣泛的取代基篩選範圍與良好的產率表現都是此方法所具有的重要特點。

This thesis describes the synthesis of 5,13-dihydro-11H-quinazalino[2,3-b]quinazolin-11-one and derivatives via copper reagent catalyst. The contents of thesis are mainly divided into two parts. The first part includes the review of literatures about copper catalyst tandem cyclization reaction and motivation of research.The second part deals with the methodology for accessing 5,13-dihydro-11H-quinazalino[2,3-b]quinazolin-11-one and derivatives from the reaction of 2-iodo-N-(2-iodobenzyl)benzamide and cyanamide in the presence of copper catalyst. The broad substrate scope and good yields are important feature of this methodology.