利用一價銠金屬經由動力學拆分催化有機硼酸及外消旋環戊烯酮：合成前列腺素及其衍生物
| dc.contributor | 吳學亮 | zh_TW |
| dc.contributor | Wu, Hsyueh-Liang | en_US |
| dc.contributor.author | 林黃櫻 | zh_TW |
| dc.contributor.author | Lin, Huang-Ying | en_US |
| dc.date.accessioned | 2019-09-04T09:12:39Z | |
| dc.date.available | 不公開 | |
| dc.date.available | 2019-09-04T09:12:39Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | 本篇論文主要為探討使用一價銠金屬與掌性雙環[2.2.2]配基L2催化芳香性及烯基硼酸試劑68對外消旋起始物(±)-70進行1,4-共軛加成反應（conjugate addition），經由動力學拆分（kinetic resolution），得到化合物109，鏡像選擇性最高達到＞99.5%，產率接近50%。將其再利用two-component的方式去合成出目標天然物前列腺素及其衍生物：PGE1 （31； 24% yield）， PGA1 methyl ester （65； 9% yield）， PGF1α （113； 24% yield）。 | zh_TW |
| dc.description.abstract | This thesis describes the enantioselective conjugate addition reaction of racemic starting material 70 with boronic acid 68 by using Rh(Ⅰ)/L2g catalyst via a with kinetic resolution manner. Compound 109 was obtained with ee up to >99.5% and the yield approximately 50%. This two-component method witnesses its synthetic applications in the synthesis of prostaglandin derivatives: PGE1 (31; 24% yield), PGA1 methyl ester (65; 9% yield), PGF1α (113; 24% yield). | en_US |
| dc.description.sponsorship | 化學系 | zh_TW |
| dc.identifier | G060542070S | |
| dc.identifier.uri | http://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22G060542070S%22.&%22.id.& | |
| dc.identifier.uri | http://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/100215 | |
| dc.language | 中文 | |
| dc.subject | 一價銠金屬 | zh_TW |
| dc.subject | 動力學拆分 | zh_TW |
| dc.subject | 外消旋環戊烯酮 | zh_TW |
| dc.subject | 前列腺素 | zh_TW |
| dc.subject | Rh(I) | en_US |
| dc.subject | Kinetic Resolution | en_US |
| dc.subject | (±)-4-Siloxy Cyclopentenones | en_US |
| dc.subject | Prostaglandins | en_US |
| dc.title | 利用一價銠金屬經由動力學拆分催化有機硼酸及外消旋環戊烯酮：合成前列腺素及其衍生物 | zh_TW |
| dc.title | Kinetic Resolution of (±)-4-Siloxy Cyclopentenones Using Rh(I)/Chiral Diene Catalysis: Synthesis of Prostaglandins | en_US |