銠金屬/掌性雙環[2.2.1]雙烯配體在γ-胺基取代的α , β-不飽和羧酸酯與芳香硼酸的不對稱1,4-加成反應之研究：合成掌性GABA及其衍生化合物之應用
| dc.contributor | 吳學亮 | zh_TW |
| dc.contributor | Wu, Hsyueh-Liang | en_US |
| dc.contributor.author | 簡嘉宏 | zh_TW |
| dc.contributor.author | Jian, Jia-Hong | en_US |
| dc.date.accessioned | 2019-09-04T09:05:35Z | |
| dc.date.available | 不公開 | |
| dc.date.available | 2019-09-04T09:05:35Z | |
| dc.date.issued | 2016 | |
| dc.description.abstract | 本論文研究主題為利用本實驗室所開發自製的掌性雙環[2.2.1]雙烯配基在γ-胺基取代的α , β-不飽和羧酸酯與芳香硼酸進行不對稱1,4-加成反應。利用三莫耳百分率的銠金屬催化試劑與L1e配基於各式不同取代的芳香硼酸親核試劑與α , β-不飽和羧酸酯反應合成出一系列掌性GABA及其衍生之化合物。反應生成的產物都具有高產率且高的鏡像超越值。產率為 63~98%，而鏡像超越值為 96~ >99.5% ee。 | zh_TW |
| dc.description.abstract | This thesis describes an efficient synthesis of highly enantioenriched 4-amino-3-aryl-butanoates via an enantioselective 1.4-addition of an array of aryboronic acids to γ-amino-α , β-unsaturated esters. In the presence of 3 mole% of the Rh(I)/ chiral diene L1e catalyst, the conjugate adducts were isolated in 63~98% yield and 96 ~ >99.5% ee. | en_US |
| dc.description.sponsorship | 化學系 | zh_TW |
| dc.identifier | G060242019S | |
| dc.identifier.uri | http://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22G060242019S%22.&%22.id.& | |
| dc.identifier.uri | http://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/99965 | |
| dc.language | 中文 | |
| dc.subject | 銠金屬催化試劑 | zh_TW |
| dc.subject | 掌性雙烯配基 | zh_TW |
| dc.subject | γ-胺基取代的α | zh_TW |
| dc.subject | β-不飽和羧酸酯 | zh_TW |
| dc.subject | Rhodium | en_US |
| dc.subject | chiral diene ligand | en_US |
| dc.subject | γ-Amino-Substituted α | en_US |
| dc.subject | β- Unsaturated Esters | en_US |
| dc.title | 銠金屬/掌性雙環[2.2.1]雙烯配體在γ-胺基取代的α , β-不飽和羧酸酯與芳香硼酸的不對稱1,4-加成反應之研究：合成掌性GABA及其衍生化合物之應用 | zh_TW |
| dc.title | Enantioselective Synthesis of γ-Amino Acids Via a Rhodium Catalyzed Asymmetric 1,4-conjugate Addition Reaction of γ-Amino-Substituted α , β- Unsaturated Esters and Arylboronic Acids | en_US |