酸催化異喹啉、吡咯化合物的合成

dc.contributor葉名倉zh_TW
dc.contributor.author吳詩慧zh_TW
dc.date.accessioned2019-09-04T10:19:15Z
dc.date.available2017-8-6
dc.date.available2019-09-04T10:19:15Z
dc.date.issued2012
dc.description.abstract含氮炔基支鏈之環氧基環己酮使用催化量的雙三氟甲基磺醯亞胺(HNTf2)進行炔-酮置換反應,得到異喹啉化合物。 3,5,5-三甲基含氮炔基支鏈之環氧基環己酮使用催化量三甲基矽基三氟甲基磺酸酯(TMSOTf)進行串列-semipinacol重排反應/炔-酮置換反應,得到吡咯化合物。 以含有氘的含氮炔基支鏈的環氧基環己醇化合物在路易士酸的催化下進行semi-pinacol重排反應及炔-酮置換反應,得到螺旋化合物。經由13C NMR光譜圖,證明含氘的碳會根據2nI+1 Rule 分裂。zh_TW
dc.description.abstractReaction of the C-2 arylpropargylsulfonamide-tethered 2,3- epoxy-cyclohexan-1-ones with a catalytic amount of HNTf2 via alkyne-ketone metathesis provided isoquinolines. Treatment of the substrates bearing a geminal dimethyl group at C-5 and a methyl group at C-3 of the ring with a catalytic amount of TMSOTf proceeded via semipinacol rearrangement/alkyne-ketone metathesis to afford pyrroles. Synthesis of 9-benzoyl-7-tosyl-7-azaspiro[4.5]dec-9-en-10-d-1-one via TfOH-catalyzed tandem semi-pinacol rearrangement/alkyne-aldehyde metathesis. According to 2nI+1 Rule, the carbon which contains deuterium will be split into 3 peaks (a triplet).en_US
dc.description.sponsorship化學系zh_TW
dc.identifierGN0699420948
dc.identifier.urihttp://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22GN0699420948%22.&%22.id.&
dc.identifier.urihttp://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/100988
dc.subject含氮炔基之鏈環氧基環己酮zh_TW
dc.subject雙三氟甲基磺醯亞胺zh_TW
dc.subject三甲基矽基三氟甲基磺酸酯zh_TW
dc.subject炔-酮置換反應zh_TW
dc.subjectC-2 arylpropargylsulfonamide-tethered 2en_US
dc.subject3- epoxy-cyclohexan-1-onesen_US
dc.subjectHNTf2en_US
dc.subjectTMSOTfen_US
dc.subjectalkyne-ketone metathesisen_US
dc.title酸催化異喹啉、吡咯化合物的合成zh_TW

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