Yatein衍生物的合成研究
| dc.contributor | 簡敦誠 | zh_TW |
| dc.contributor | Chien, Tun-Cheng | en_US |
| dc.contributor.author | 韓孟儒 | zh_TW |
| dc.contributor.author | Han, Meng-Ru | en_US |
| dc.date.accessioned | 2022-06-08T02:42:15Z | |
| dc.date.available | 9999-12-31 | |
| dc.date.available | 2022-06-08T02:42:15Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | 依託泊苷(etoposide)用於治療多種惡性腫瘤及癌症，但製備須從鬼臼屬植物中分離(-)-鬼臼毒素((–)-podophyllotoxin)，再經由人工合成得到。(-)-鬼臼毒素的生物合成是由松柏醇(coniferyl alcohol)經多步驟的酵素催化反應。本實驗室有興趣的部分在於(–)-yatein 在 2-ODD 素作用下，進行分子內合環反應形成(-)-去氧鬼臼毒素的機制。為了探討酵素的反應機制，我們合成 7'-hydroxy yatein及(-)-yatein、(+)-yatein 作為酵素反應的受質，並確定各個產物的來源及 7'-hydroxy yatein 相對及絕對立體構形。 | zh_TW |
| dc.description.abstract | Etoposide can be used to treat a variety of malignant tumors and cancers. However, the production requires isolation of (–)-podophyllotoxin from the medicinal plant Podophyllum, followed by multi-step chemical synthesis. The biosynthesis of (–)- podophyllotoxin was accomplished from coniferyl alcohol via multiple enzyme catalysis. In the biosynthetic pathway of (–)-podophyllotoxin, we have been interested to establish a reasonable reaction mechanism for (–)-deoxypodophyllotoxin from yatein under 2-ODD-catalyzed oxidative cyclization. In order to explore the mechanism of enzymatic reaction, we synthesized 7'-hydroxy yatein, (-)-yatein and (+)-yatein as substrates for the enzymatic reaction. We determined the source of each product and the relative and absolute configuration of 7'-hydroxy yatein. | en_US |
| dc.description.sponsorship | 化學系 | zh_TW |
| dc.identifier | 60842065S-40485 | |
| dc.identifier.uri | https://etds.lib.ntnu.edu.tw/thesis/detail/efef8068ddfe6c806602bc0409375e1e/ | |
| dc.identifier.uri | http://rportal.lib.ntnu.edu.tw/handle/20.500.12235/117249 | |
| dc.language | 中文 | |
| dc.subject | none | zh_TW |
| dc.subject | none | en_US |
| dc.title | Yatein衍生物的合成研究 | zh_TW |
| dc.title | Synthetic Studies toward Yatein Derivatives | en_US |
| dc.type | 學術論文 |