GREENER APPROACHES TOWARDS THE SYNTHESIS OF PHARMACEUTICALLY ACTIVE N, O, S-HETEROCYCLES AND ANTIBACTERIAL AGENTS

Abstract

本論文主要的目標是發展新的綠色化學的合成方式及抗菌劑的和成。 此論文分成三個章節。第一章節分為兩部分，A部分是介紹不需使用催化劑，即可使吲哚加成至β-硝基苯乙烯。B部分則是介紹不需使用溶劑，即可使吡咯與吲哚加成至β-硝基苯乙烯。 第二章節為利用在水中且無催化劑之條件下，促進吲哚與2-aryl-3-2H-chromenes進行烷基化反應。 第三章節亦分為兩部分，A部分介紹有關[3+2]-環加成反應。B部分是介紹3-phenyl-5-((4-phenyl-2-(phenylimino)thiazol-3(2H)-yl)methyl)oxazo- lidin-2-one的合成。

The dissertation is divided into three chapters. The first chapter is divided into two sections, Section A deals with the catalyst-free aqueous mediated conjugative addition of indoles to β-nitrostyrenes and Section B describes the conjugative addition of pyrrole and indole to β-nitroalkenes under solvent free condition (SFC). Second chapter provides a detailed study of “On-Water” promoted C-alkylation of indoles with 2-aryl-3-2H-chromenes under catalyst-free conditions’’ and mechanistic insights. Third chapter is divided into three sections A, B and C; Section A and B which describe the [3+2]-cycloaddition synthesis of 4-aryl-1,4-dihydrochromeno[4,3-d] [1,2,3]triazole and triazole-oxazolidinones derivatives respectively. Section C deals with the synthesis of a new class oxazolidinone C-5-(aryl-imino)thiazo and pharmacologically active Linezolid analogues.