有機催化α,β-不飽和醛及2-羥基苯甲醛苯腙製備四取代1,3,4,5-吡唑化合物
| dc.contributor | 陳焜銘 | zh_TW |
| dc.contributor | Kwun-min Chen | en_US |
| dc.contributor.author | 杜懿珊 | zh_TW |
| dc.contributor.author | Duh, Yih-Shan | en_US |
| dc.date.accessioned | 2020-12-14T08:58:34Z | |
| dc.date.available | 2020-08-25 | |
| dc.date.available | 2020-12-14T08:58:34Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | 本題目為利用有機催化反應，合成四取代1,3,4,5-吡唑化合物。在此反應中，以20 mol% DL-脯胺酸為催化劑，進行巴豆醛及苯腙之 [3+2]-環加成反應，芳香化後得到產物吡唑，產率30-51%。DL-脯胺酸首先活化巴豆醛，生成亞胺離子中間體，與苯腙進行 [3+2]-環化反應，芳香化後，便得到四取代吡唑化合物。 | zh_TW |
| dc.description.abstract | An organocatalytic synthesis of 1,3,4,5-tetrasubstituted pyrazole was described. In this study, 20 mol% DL-proline catalyzed the [3+2] cycloaddition of crotonaldehyde with phenylhydrazone followed by aromatization, leading to the pyrazole formation in moderate yield (30-51%). DL-proline activated crotonaldehyde by in situ generation of imium ion intermediate, so that the [3+2] cyclization with phenylhydrazone and aromatization could proceed. | en_US |
| dc.description.sponsorship | 化學系 | zh_TW |
| dc.identifier | G060742031S | |
| dc.identifier.uri | http://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22G060742031S%22.& | |
| dc.identifier.uri | http://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/111140 | |
| dc.language | 中文 | |
| dc.subject | none | zh_TW |
| dc.subject | none | en_US |
| dc.title | 有機催化α,β-不飽和醛及2-羥基苯甲醛苯腙製備四取代1,3,4,5-吡唑化合物 | zh_TW |
| dc.title | Organocatalytic Synthesis of 1,3,4,5-Tetrasubstituted Pyrazole from α,β-Unsaturated Aldehyde and 2-Hydroxybenzaldehyde Phenylhydrazone | en_US |
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