藉由銅催化級聯反應將 2-碘聯苯醯胺衍生物與 2-炔基芐基氰化物合成出二苯並[c,f][1,8]萘啶-5(6H)-酮衍生物與亞氨基異吲哚衍生物

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dc.contributor姚清發zh_TW
dc.contributorYao, Ching-Faen_US
dc.contributor.author黎准滺zh_TW
dc.contributor.authorLi, Chun-Youen_US
dc.date.accessioned2020-12-14T08:58:42Z
dc.date.available2020-09-01
dc.date.available2020-12-14T08:58:42Z
dc.date.issued2020
dc.description.abstract本論文分為兩個章節。第一章為緒論，包括對 1,8-萘啶的介紹與其衍生物的合成和性質的文獻回顧。本章節還介紹了有關異吲哚啉1-酮的衍生物、銅催化反應、區域選擇性轉換反應與薗頭反應的文獻回顧。在末尾的部份，我們還敘述了研究目標與動機。 第二章分為兩個部份。第一部份為利用 2-碘苯甲醯胺與 2-溴苯基乙炔進行薗頭偶聯反應，進一步得到相應的亞氨基異吲哚啉-1-酮衍生物，並在後續鈀催化條件下進行赫克反應，分子內合環後得到相應的苯並稠合的異吲哚啉-1-酮衍生物。另一部分為在碳酸銫的鹼性條件下以二甲基亞碸為溶劑，將 2-氨基苯甲醯胺衍生物和 2-炔基芐基氰化物進行銅催化級聯反應得到 1,8-萘啶衍生物，並在碳酸鉀的條件下製備出亞氨基異吲哚衍生物。zh_TW
dc.description.abstractThis thesis is divided in two chapters. The first chapter dealt with preface of the thesis which includes the introduction to 1,8-naphtharidine derivatives and literature survey on the synthesis and properties of 1,8- naphtharidine derivatives. In addition, this chapter introduce short literature descriptions about isoindolinone derivatives, copper catalyzed reactions, regioselective-switching reactions and Sonogashira coupling reactions. Further, we then disclosed the aim and research goals at the end of the first chapter. The second chapter consists two parts. The first part describes about the synthesis of 1,8-naphtharidine derivatives through copper catalyzed tandem cyclization of 2-idobenzamide derivatives and 2-alkynylbenzylcyanides in DMSO using cesium carbonate as base and further the same reaction furnished iminoisoindole derivatives using potassium carbonate as base. The next part is Sonogashira coupling reaction of 2-iodobenzamide derivatives and 2-bromophenylacetylenes to obtain corresponding isoindolinone derivatives. The resulted isoindole derivatives further converted into corresponding benzofusedisoindolinone derivatives through palladium catalyzed Heck coupling.en_US
dc.description.sponsorship化學系zh_TW
dc.identifierG060742040S
dc.identifier.urihttp://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22G060742040S%22.&
dc.identifier.urihttp://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/111148
dc.language中文
dc.subjectnonezh_TW
dc.subjectnoneen_US
dc.title藉由銅催化級聯反應將 2-碘聯苯醯胺衍生物與 2-炔基芐基氰化物合成出二苯並[c,f][1,8]萘啶-5(6H)-酮衍生物與亞氨基異吲哚衍生物zh_TW
dc.titleSynthesis of dibenzo[c,f][1,8]naphthyridine-5(6H)-one and iminoisoindole derivatives via copper-catalyzed tandem reaction of substituted 2-iodobenzamides and 2-alkynylbenzylcyanidesen_US

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