銠金屬 (I) /掌性雙烯配體芳香族硼酸對芳香亞胺進行不對稱加成反應及掌性咪唑的合成應用
Abstract
本文描述以一價銠金屬和掌性雙烯配基 (75 C) 所形成錯合物為催化劑催化芳香基硼酸試劑 (arylboronic acid) 與二苯基次磷醯亞胺進行不對稱芳香基加成反應，可以有效合成一系列具有高鏡像選擇性以二苯基次磷酸根保護的雙芳香環甲基胺類化合物。在 3 mol% 的銠金屬和掌性雙烯配體形成之催化劑反應下，可得到加成產物有31-99% 產率，具有 90- 99% 的鏡像超越值，此催化方法亦應用在合成掌性咪唑上。
Chiral diarylmethylamines with a P,P-diphenylphosphinic- protecting groups were prepared from the asymmetric addition of a range of arylboronic acids to N-(P,P-diphenylphosphinoyl) imines in presence of Rh(I) and chiral ligand 75 C. This process offers the 1,2-adducts in good yields (55-99 %) and excellent enantioselectivies (ee value up to 99 %) for various arylboronic acids and aldimines.
Chiral diarylmethylamines with a P,P-diphenylphosphinic- protecting groups were prepared from the asymmetric addition of a range of arylboronic acids to N-(P,P-diphenylphosphinoyl) imines in presence of Rh(I) and chiral ligand 75 C. This process offers the 1,2-adducts in good yields (55-99 %) and excellent enantioselectivies (ee value up to 99 %) for various arylboronic acids and aldimines.
Description
Keywords
不對稱合成, 銠金屬, asymmetric addition