掌性環亞基胺-N-氧化物化學: 多羥基吡咯和哌啶生物鹼的製備

dc.contributor陳建添 博士zh_TW
dc.contributorChien-Tien, Chenen_US
dc.contributor.author葉耀廷zh_TW
dc.contributor.authorYao-Ting, Yehen_US
dc.date.accessioned2019-09-04T09:46:17Z
dc.date.available不公開
dc.date.available2019-09-04T09:46:17Z
dc.date.issued2008
dc.description.abstract多羥基吡咯和哌啶生物鹼的化合物結構吸引很多的化學合成家的注意,因其驚人的生物活性和具有作為藥物的的潛力,特別是在治療癌症、糖尿病和病毒的傳染病過程中作為醣水解酵素抑制劑。 因此發展新的方法合成多羥基吡咯和哌啶的化合物是相當的重要,尤其是此類環形結構的掌性衍生物。 在這論文中,我們利用D-木糖為起始物,發展新的合成方法,且有效率的合成多羥基吡咯和哌啶衍生物,以評估其生物活性。zh_TW
dc.description.abstractThe chiral polyhydroxy alkaloids have attracted considerable attention in organic synthesis owing to their remarkable biological properties and their potential as pharmaceuticals, especially, to serve as glycosidase inhibitors in treatment of cancers, diabetes and viral infections. The development of new methods for the synthesis of pyrrolidine- or piperidine-based compounds is therefore of considerable importance, particularly for the approaches leading to chiral derivatives of these ring skeletons. In this thesis, we have developed new and efficient synthetic protocols to prepare various polyhydroxylated pyrrolidine and piperidine-based alkaloids from D-xylose to evaluate their biological activities.en_US
dc.description.sponsorship化學系zh_TW
dc.identifierGN0695420562
dc.identifier.urihttp://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22GN0695420562%22.&%22.id.&
dc.identifier.urihttp://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/100658
dc.language中文
dc.subject多羥基吡咯zh_TW
dc.subject多羥基哌啶zh_TW
dc.subject醣水解酵素抑制劑zh_TW
dc.subject環亞基胺-N-氧化物zh_TW
dc.subjectPolyhydroxylated pyrrolidineen_US
dc.subjectPolyhydroxylated piperidineen_US
dc.subjectglycosidase inhibitorsen_US
dc.subjectCyclic nitroneen_US
dc.title掌性環亞基胺-N-氧化物化學: 多羥基吡咯和哌啶生物鹼的製備zh_TW
dc.titleChiral Cyclic Nitrone Chemistry: Preparation of Polyhydroxylated Pyrrolidine and Piperidine Alkaloidsen_US

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