便宜而有效合成吲哚類雜環化合物方法之研究

Abstract

第一個題目分為兩個部份，第一部份使用碘化亞銅 (copper (I) iodide) 當作催化劑，將二亞苄基丙酮衍生物 (dibenzolideneacetone derivatives) 與苯肼 (phenylhydrazine) 進行環化反應生成吡唑啉(pydrazoline) 衍生物後，再氧化生成吡唑 (pyrazole) 衍生物並以一鍋化反應進行。同時，根據文獻指出，吡唑衍生物具有生物活性，常見於農用化學品和藥物結構中，如殺蟲劑Cyenopyrafen、吡蟎胺、唑蟲酰胺、唑蟎酯和非類固醇消炎止痛藥希樂葆。 第二部份則是利用二亞苄基丙酮衍生物與苯甲醯肼 (benzoyl hydrazine) 進行反應獲得亞胺 (imine) 衍生物後，在無金屬或酸催化劑的條件下，以微波反應器在短時間內得到1,3,4–噁二唑 (1,3,4–oxadiazole) 衍生物，而1,3,4–噁二唑 (oxadiazole) 衍生物具有生物活性，許多常見藥物都是1,3,4–噁二唑衍生物。 第二個題目是利用吡唑衍生物與對苯醌 (p–Benzoquinone，BQ) 進行Diels–Alder 反應，在不使用催化劑的條件下，只使用甲苯與醋酸就可得到咔唑 (carbazole) 衍生物。我們在此合成多種取代基的咔唑衍生物。咔唑衍生物具有生物活性，如Clausamines A–G對淋巴瘤細胞具有抗腫瘤的效果。

The thesis is divided into two chapters. The first chapter is subdivided into two sections. The first section chapter I describes the synthesis of pyrazole derivatives from the dibenzolideneacetone derivatives and phenylhydrazines via copper (I) iodide catalyzed one-pot oxidative C-H amination and aromatization. The pyrazole moiety is present in many important agrochemical and pharmaceutical products, such as the pesticides Cyenopyrafen, Tebufenpyrad, Tolfenpyrad, Fenpyroximate, and nonsteroidalanti-inflammatory drug Celecoxib. The second section of Chapter I deals with the synthesis of 1,3,4-oxadiazole derivatives. This method involves the reaction of indole adduct of dibenzolideneacetone derivatives with acylphenylhydrazine in the presence of acetic anhydride under microwave irradiation. This reaction did not need any metal or acidic catalyst. 1,3,4-oxadiazole derivatives possess biological activities and are common drugs structure. The chapter II describes the synthesis of carbazole derivatives from the reaction of indole adduct of dibenzolideneacetone phenylhydrazine and benzoquinone in absence of catalyst in toluene and acetic acid. A wide variety of substituted carbazole derivatives were synthesized in this procedure. Carbazole derivatives possess biological activities, such as Clausamines A-G shows activity of antitumor on Raji cell.