利用一價銠金屬進行不對稱1,4-加成反應對三尖杉鹼天然物全合成之合成研究

dc.contributor吳學亮zh_TW
dc.contributorWu, Hsyueh-Liangen_US
dc.contributor.author呂怡柔zh_TW
dc.contributor.authorLu, Yi-Rouen_US
dc.date.accessioned2020-10-19T06:51:15Z
dc.date.available2025-09-10
dc.date.available2020-10-19T06:51:15Z
dc.date.issued2020
dc.description.abstract本篇論文探討利用一價銠金屬及掌性雙環[2.2.1]雙烯配基L1形成之催化劑催化芳香基硼酸試劑48對環狀α,β-不飽和β-酮酯47進行不對稱1,4-加成反應。生成加成產物46為單一非鏡像異構物有產率67–99%及鏡像超越值66–99%。此加成產物46可再進行烷基化反應(C-alkylation),建構掌性四級碳之產物45,其產物45產率43–94%及鏡像超越值66–98%。本論文探討利用此方法應用在合成天然物(−)-Cephalotaxine之可能性zh_TW
dc.description.abstractThis thesis studies the asymmetric 1,4-addition reaction of arylboronic acids 48 to cyclic α,β-unsaturated β-ketoester 47 catalyzed by a Rh(I)/chiral diene ligand L1 catalyst. The adducts 46 were obtained as a single diastereomer in up to 99% yield and with up to 99% ee. Furthermore, the adducts 46 underwent C-alkylaion reaction to provide products 45 with a chiral quaternary stereogenic center in up to 94% yield and with up to 98% ee. This method was used for the synthetic study toward the total synthesis of natural product (−)-Cephalotaxine.en_US
dc.description.sponsorship化學系zh_TW
dc.identifierG060742051S
dc.identifier.urihttp://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22G060742051S%22.&%22.id.&
dc.identifier.urihttp://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/111155
dc.language中文
dc.subject一價銠金屬zh_TW
dc.subject掌性雙環[2.2.1]雙烯配基zh_TW
dc.subject環狀α,β-不飽和β-酮酯zh_TW
dc.subject不對稱1,4-加成反應zh_TW
dc.subject天然物zh_TW
dc.subjectRh(I)/chiral diene ligand catalysten_US
dc.subjectasymmetric 1,4-addition reactionen_US
dc.subjectα,β-unsaturated β-ketoesteren_US
dc.subjectnatural producten_US
dc.title利用一價銠金屬進行不對稱1,4-加成反應對三尖杉鹼天然物全合成之合成研究zh_TW
dc.titleA Synthetic Study Toward the Total Synthesis of (−)-Cephalotaxine Using Rh(I)-Catalyzed Enantioselective 1,4-Addition Reactionen_US

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