I.銠(I)金屬結合掌性配位體催化不對稱1,4-加成在-Nitrostyrenes化合物及應用在3,4-二氫異喹啉和(S)-SKF 38393的形式合成。II.銠(I)金屬結合掌性配位體催化不對稱1,4-加成在-Nitroacrylate化合物。

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dc.contributor吳學亮zh_TW
dc.contributor.author黃崑致zh_TW
dc.date.accessioned2019-09-04T10:03:45Z
dc.date.available不公開
dc.date.available2019-09-04T10:03:45Z
dc.date.issued2013
dc.description.abstract第一部分:敘述以銠(I)金屬掌性雙烯為配基(L4)錯合物催化芳香基硼酸試劑(Arylboronic acid)進行不對稱芳香基加成反應合成出一系列具有不對稱中心之雙芳香環硝基甲烷類化合物(Diarylnitroethane)。此反應可以不同芳香基硼酸試劑和-硝基苯乙烯(-nitrostyrene)進行反應，而得到不錯的產率和高立體選擇性的加成產物，其鏡性超越值最高可達到97%。此合成方法最後也利用在合成藥物3,4-二氫異喹啉(3,4-dihydroisoquinoline)以及(S)-SKF 38393上。 第二部分:敘述以銠(I)金屬掌性雙烯為配基(L4)錯合物，催化芳香基硼酸試劑(Arylboronic acid)進行不對稱芳香基加成反應至-硝基丙烯酸酯(-Nitroacrylate)，實驗結果可以的到不錯的產率，以及良好的鏡像選擇性，進一步合成出-胺基酸(-amino acid)的前驅物。zh_TW
dc.description.abstractPart 1:Chiral diarylnitroethane were prepared from the asymmetric addition of a range of arylboronic acids to -nitrostyrene in the presence of Rh(I) diene complex. This process offers the 1,4-adducts in good yields and excellent enantioselectivities (ee value up to 97%) for various arylboronic acids and -nitrostyrene. This synthesis method is also used in the synthesis of 3,4-dihydroisoquinoline and (S)-SKF 38393. Part 2:The asymmetric addition of phenylboronic acids to -nitroacrylate in the presence of Rh(I) diene complex. This process offers the 1,4-adducts in good yields and excellent enantioselectivities(ee value up to 95%) for phenylboronic acids and -nitroacrylate. Further synthesis of 2,2-amino acid precursors.en_US
dc.description.sponsorship化學系zh_TW
dc.identifierGN0698420329
dc.identifier.urihttp://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22GN0698420329%22.&%22.id.&
dc.identifier.urihttp://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/100864
dc.language中文
dc.subject銠(I)金屬zh_TW
dc.titleI.銠(I)金屬結合掌性配位體催化不對稱1,4-加成在-Nitrostyrenes化合物及應用在3,4-二氫異喹啉和(S)-SKF 38393的形式合成。II.銠(I)金屬結合掌性配位體催化不對稱1,4-加成在-Nitroacrylate化合物。zh_TW

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