(1) Benzimidazoles的合成研究 (2) 銅金屬催化Indoles的合成研究

dc.contributor簡敦誠zh_TW
dc.contributor.author廖本原zh_TW
dc.date.accessioned2019-09-04T09:26:13Z
dc.date.available不公開
dc.date.available2019-09-04T09:26:13Z
dc.date.issued2014
dc.description.abstract本篇論文分為兩個部分,第一部分為合成在胺基上具有不同取代基的雜環carboxamidoxime,並以此carboxamidoxime為起始物,利用p-toluenesulfonic anhydride作為sulfonyllating 試劑,在低溫下進行親電性芳香環取代反應,得到2位具有雜環的bezimidazole衍生物。另外,我們亦探討carboxamidoxime在不同的sulfonylating 試劑下進行Tienmann 重排反應而形成N,N’-雙取代urea衍生物。 第二部分為3-cyanoindole衍生物的合成研究,以鄰位有鹵素的aniline或是benzonitrile作為起始物,合成出N-(o-ethynylphenyl)-N-toylcyanamide衍生物。最後在銅催化下得到合環的3-cyanoindole衍生物。zh_TW
dc.description.abstractThis thesis covers two separated topics. The first part is the synthesis of N-phenyl hetero-aryl carboxamidoximes with different substituents on the bezene ring. The reaction of the N-phenyl hetero-aryl carboxamidoximes with p-toluenesulfonic anhydride undergoes a direct intramolecular electrophilic aromatic substitution at low temperature, to afford 2-hetero-arylbenzimidazole derivatives. Moreover, we also found that the reaction of arylcarboxamidoximes with different sulfonyl reagents undergo Tiemann rearrangement reaction to afford corresponding of N,N’-disubstituted ureas. The second part focuses on studying the synthesis of 3-cyanoindole derivatives. N-(o- ethynylphenyl)- N-tosylcyanamide derivatives were prepared from corresponding o-haloanilines or o-halobenzonitrile. 3-Cyanoindole derivatives were obtained when treatment of o-ethynylphenyl cyanamides with a catalytic amount of CuI.en_US
dc.description.sponsorship化學系zh_TW
dc.identifierGN060142041S
dc.identifier.urihttp://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22GN060142041S%22.&%22.id.&
dc.identifier.urihttp://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/100433
dc.language中文
dc.subject醯胺肟zh_TW
dc.subject苯併咪唑zh_TW
dc.subject一價銅催化zh_TW
dc.subject吲哚zh_TW
dc.subjectcarboxamidoximeen_US
dc.subjectbenzimidazoleen_US
dc.subjectcopper (I) catalysten_US
dc.subjectindoleen_US
dc.title(1) Benzimidazoles的合成研究 (2) 銅金屬催化Indoles的合成研究zh_TW
dc.title(1) Synthetic Studies of Benzimidazoles from Amidoximes (2) Copper-Catalyzed Synthesis of Indolesen_US

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