(1) Benzimidazoles的合成研究 (2) 銅金屬催化Indoles的合成研究
| dc.contributor | 簡敦誠 | zh_TW |
| dc.contributor.author | 廖本原 | zh_TW |
| dc.date.accessioned | 2019-09-04T09:26:13Z | |
| dc.date.available | 不公開 | |
| dc.date.available | 2019-09-04T09:26:13Z | |
| dc.date.issued | 2014 | |
| dc.description.abstract | 本篇論文分為兩個部分，第一部分為合成在胺基上具有不同取代基的雜環carboxamidoxime，並以此carboxamidoxime為起始物，利用p-toluenesulfonic anhydride作為sulfonyllating 試劑，在低溫下進行親電性芳香環取代反應，得到2位具有雜環的bezimidazole衍生物。另外，我們亦探討carboxamidoxime在不同的sulfonylating 試劑下進行Tienmann 重排反應而形成N,N’-雙取代urea衍生物。 第二部分為3-cyanoindole衍生物的合成研究，以鄰位有鹵素的aniline或是benzonitrile作為起始物，合成出N-(o-ethynylphenyl)-N-toylcyanamide衍生物。最後在銅催化下得到合環的3-cyanoindole衍生物。 | zh_TW |
| dc.description.abstract | This thesis covers two separated topics. The first part is the synthesis of N-phenyl hetero-aryl carboxamidoximes with different substituents on the bezene ring. The reaction of the N-phenyl hetero-aryl carboxamidoximes with p-toluenesulfonic anhydride undergoes a direct intramolecular electrophilic aromatic substitution at low temperature, to afford 2-hetero-arylbenzimidazole derivatives. Moreover, we also found that the reaction of arylcarboxamidoximes with different sulfonyl reagents undergo Tiemann rearrangement reaction to afford corresponding of N,N’-disubstituted ureas. The second part focuses on studying the synthesis of 3-cyanoindole derivatives. N-(o- ethynylphenyl)- N-tosylcyanamide derivatives were prepared from corresponding o-haloanilines or o-halobenzonitrile. 3-Cyanoindole derivatives were obtained when treatment of o-ethynylphenyl cyanamides with a catalytic amount of CuI. | en_US |
| dc.description.sponsorship | 化學系 | zh_TW |
| dc.identifier | GN060142041S | |
| dc.identifier.uri | http://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22GN060142041S%22.&%22.id.& | |
| dc.identifier.uri | http://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/100433 | |
| dc.language | 中文 | |
| dc.subject | 醯胺肟 | zh_TW |
| dc.subject | 苯併咪唑 | zh_TW |
| dc.subject | 一價銅催化 | zh_TW |
| dc.subject | 吲哚 | zh_TW |
| dc.subject | carboxamidoxime | en_US |
| dc.subject | benzimidazole | en_US |
| dc.subject | copper (I) catalyst | en_US |
| dc.subject | indole | en_US |
| dc.title | (1) Benzimidazoles的合成研究 (2) 銅金屬催化Indoles的合成研究 | zh_TW |
| dc.title | (1) Synthetic Studies of Benzimidazoles from Amidoximes (2) Copper-Catalyzed Synthesis of Indoles | en_US |