金(I)和三氯化鐵共輔佐4-炔醯胺環己-2-烯醇衍生物的分子內環化反應-苯氮呯及六氫吲哚酮衍生物的合成

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dc.contributor葉名倉zh_TW
dc.contributorYeh, Ming-Changen_US
dc.contributor.author胡婷嘉zh_TW
dc.contributor.authorHu, Ting-Chiaen_US
dc.date.accessioned2019-09-04T09:05:42Z
dc.date.available不公開
dc.date.available2019-09-04T09:05:42Z
dc.date.issued2015
dc.description.abstract本文分別探討以金、銀與三氯化鐵共輔佐及單獨以三氯化鐵作為路易士酸輔佐4-炔醯胺環己-2-烯醇衍生物進行分子內環化反應。第一部分探討以三氯化鐵輔佐4-炔醯胺-1-矽氧基環己-2-烯醇衍生物，在室溫及氮氣下進行Friedel-Craft反應合成氯化二苯氮呯衍生物。以金、4-炔醯胺-1-矽氧基環己-2-烯醇衍生物銀與三氯化鐵共輔佐4-炔醯胺-1-矽氧基環己-2-烯醇衍生物在室溫及氮氣下生成keteniminium和金碳烯中間體後，進行碳-鹵化反應得到六氫吲哚酮衍生物。第二部分探討4-炔醯胺-1-乙醯氧基環己-2-烯在三氯化鐵輔佐及金、銀與三氯化鐵共催化下，生成keteniminium和碳烯中間體後，進行反式碳－鹵化反應得到六氫吲哚酮衍生物。zh_TW
dc.description.abstractThis thesis focuses on gold(I)/silver/iron trichloride-copromoted and iron trichloride-promoted intramolecular cyclolization of cyclic 2-enynamides. First, iron trichloride promoted intramolecular cyclization of 1-siloxy-4-ynamidocyclohex-2-enes under nitrogen at room temperature proceeded via Friedel-Craft reaction to produced benzazeprine derivatives. Gold(I)/iron trichloride-copromoted 1-siloxy-4-ynamidocyclohex-2-enes under nitrogen at room temperature afforded oxindole derivatives with good stereoselectivity. The carbohalogenation was suggested via formation of the transient keteniminium ion and gold-carbene intermediates. Second, gold(I)/iron trichloride-copromoted cyclization of 1-acetoxy-4-ynamidocyclohex-2-enes under nitrogen at room temperature generated hexahydroxindole derivatives via carbohalogenation.en_US
dc.description.sponsorship化學系zh_TW
dc.identifierG060242038S
dc.identifier.urihttp://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22G060242038S%22.&%22.id.&
dc.identifier.urihttp://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/99972
dc.language中文
dc.subject三氯化鐵zh_TW
dc.subject炔醯胺化合物zh_TW
dc.subject分子內環化zh_TW
dc.subject氯化二苯氮呯衍生物zh_TW
dc.subject金銀與三氯化鐵共輔佐zh_TW
dc.subject碳-鹵化反應zh_TW
dc.subject六氫吲哚酮衍生物zh_TW
dc.subjectiron trichlorideen_US
dc.subjectenynamidesen_US
dc.subjectintramolecular cyclolizationen_US
dc.subjectbenzazeprineen_US
dc.subjectgold(I)/silver/iron trichloride-copromoteden_US
dc.subjectcarbohalogenationen_US
dc.subjecthexahydroxindoleen_US
dc.title金(I)和三氯化鐵共輔佐4-炔醯胺環己-2-烯醇衍生物的分子內環化反應-苯氮呯及六氫吲哚酮衍生物的合成zh_TW
dc.titleStereoselective Synthesis of Benzoazepines and Hexahydroxindoles via Gold(I)/Iron trichloride-copromoted Carbohalogenation of 4-ynamidocyclohex-2-enols.en_US

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