應用多種策略和成具有生物活性的含氮及氧雜環化合物

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dc.contributor姚清發zh_TW
dc.contributorYao, Ching-Faen_US
dc.contributor.author溫斯林zh_TW
dc.contributor.authorR.R.Rajawinslinen_US
dc.date.accessioned2019-09-04T09:15:17Z
dc.date.available2016-09-18
dc.date.available2019-09-04T09:15:17Z
dc.date.issued2015
dc.description.abstract本文的內容分為兩部分。第一部分被細分成三個部分。 A節描述了將SelectFluor介導的氟化反應的概述。 B節描述了“將SelectFluor介導的氟化和C-C鍵斷裂環己烯稠合的異噁唑啉N-氧化物”。在本節中，一個快速的方法使用的CC鍵斷裂以及這些化合物的合成的效用長鏈氟化合物的合成進行說明。 C部分描述了“將SelectFluor介導的一鍋煮合成環己酮環的稠合異噁唑衍生物”。第二部分還細分成三個部分。 A節描述的鐵/乙酸介導的反應，還原環化反應的重要性在概述中有機合成及最近報導的從我們集團鐵/乙酸介導的協議。 B節描述了“鐵/乙酸介導的分子間串聯CC和CN鍵的形成：一個容易獲得吖啶和喹啉衍生物”。在本節中，一個快速的方法的生物活性化合物的合成通過使用鐵/乙酸進行說明。 C部分描述了“鐵/乙酸介導的合成6,7-二氫[B，D]通過分子內還原cylization [1,7]菲羅啉衍生物”。在本節中，一個簡單的方法用於多環化合物的合成通過使用鐵/乙酸以及它們的新合成的化合物的合成的效用進行了描述。zh_TW
dc.description.abstractThe content of this dissertation is divided into two parts. Part I is subdivided into three sections. Section A describes the overview on Selectfluor mediated fluorination reactions. Section B describes the “Selectfluor-mediated fluorination and C–C bond cleavage of cyclohexene-fused isoxazoline N-oxides”. In this section, a rapid method for the synthesis of long chain fluoro compounds using C-C bond cleavage and the synthetic utility of these compounds are described. Section C describes the “Selectfluor mediated one-pot synthesis of cyclohexanone ring fused isoxazole derivatives”. Part II also subdivided into three sections. Section A describes the overview of iron/acetic acid mediated reactions, importance of reductive cyclization reactions in organic synthesis and the recently reported iron/acetic acid mediated protocols from our group. Section B describes the “Iron/Acetic acid mediated intermolecular tandem C-C and C-N bond formation: An easy access to acridinone and quinoline derivatives”. In this section, a rapid method for the synthesis of biologically active compounds by using iron/acetic acid is described. Section C describes the “Iron/acetic acid mediated synthesis of 6,7-dihydrodibenzo [b,j] [1,7] phenanthroline derivatives via intramolecular reductive cylization”. In this section, an easy method for the synthesis of polycyclic compounds by using iron/acetic acid and the synthetic utility of these newly synthesized compounds are described.en_US
dc.description.sponsorship化學系zh_TW
dc.identifierG080042008S
dc.identifier.urihttp://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22G080042008S%22.&%22.id.&
dc.identifier.urihttp://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/100272
dc.language英文
dc.subject四氟硼酸zh_TW
dc.subject氟化反應zh_TW
dc.subject環裂解zh_TW
dc.subject碳-碳鍵斷裂zh_TW
dc.subjectSelectfluoren_US
dc.subjectFluorinationen_US
dc.subjectRing cleavageen_US
dc.subjectIsoxazoline N-Oxideen_US
dc.subjectC-C bond cleavageen_US
dc.subjectSynthetic methodsen_US
dc.subjectDefluorinationen_US
dc.subjectN-O Couplingen_US
dc.subjectHeterocyclesen_US
dc.title應用多種策略和成具有生物活性的含氮及氧雜環化合物zh_TW
dc.titleMULTIFACETED APPROACH TOWARDS THE SYNTHESIS OF BIOLOGICALLY ACTIVE O, N - HETEROCYCLESen_US

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