一鍋多組份合成α-四氫吡咯苯烷酮類新興濫用物質與氣相層析質譜分析 One-pot Multi-component Synthesis of α-Pyrrolidinophenones and Analysis via Gas Chromatography–Mass Spectrometry

dc.contributor 姚清發 zh_TW
dc.contributor Yao, Ching-Fa en_US
dc.contributor.author 邱冠維 zh_TW
dc.contributor.author Chiu, Kuan-Wei en_US
dc.date.accessioned 2019-09-04T09:09:49Z
dc.date.available 2018-01-28
dc.date.available 2019-09-04T09:09:49Z
dc.date.issued 2018
dc.description.abstract 本論文探討以三步驟合成新興濫用物質α-四氫吡咯苯烷酮衍生物及其分析,利用條件溫和且易取得之化學原料,以佛瑞德-克來福特醯化反應,讓起始物一次與六種烷基醯氯進行反應、再經過α-溴化及胺化反應後,迅速合成出六種α-四氫吡咯苯烷酮之衍生物,並透過改變起始物合成出一系列之衍生物,所得產物再以氣相層析質譜儀進行分析,建立起此類新興濫用物質及其中間產物的標準圖譜。 關鍵字(詞):新興精神活性物質、α-四氫吡咯苯烷酮類、氣相層析質譜分析 zh_TW
dc.description.abstract This essay focuses on the one-pot multi-component synthesis of α-pyrrolidinophenones. Using a three steps process. The starting material and six types of alky acyl chloride undergo Friedel-Crafts acylation, α-bromination and amination reactions. This process swiftly synthesis six types of α-pyrrolidinophenones and its intermediate products, then by changing the starting material can get different derivatives. All products are then analyzed via gas chromatography–mass spectrometry to establish a complete mass spectrum database. Keywords:Novel Psychoactive Substances, α-Pyrrolidinophenones, Gas Chromatography–Mass Spectrometry en_US
dc.description.sponsorship 化學系 zh_TW
dc.identifier G060442068S
dc.identifier.uri http://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22G060442068S%22.&%22.id.&
dc.identifier.uri http://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/100139
dc.language 中文
dc.subject 新興精神活性物質 zh_TW
dc.subject α-四氫吡咯苯烷酮類 zh_TW
dc.subject 氣相層析質譜分析 zh_TW
dc.subject Novel Psychoactive Substances en_US
dc.subject α-Pyrrolidinophenones en_US
dc.subject Gas Chromatography–Mass Spectrometry en_US
dc.title 一鍋多組份合成α-四氫吡咯苯烷酮類新興濫用物質與氣相層析質譜分析 zh_TW
dc.title One-pot Multi-component Synthesis of α-Pyrrolidinophenones and Analysis via Gas Chromatography–Mass Spectrometry en_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
060442068s01.pdf
Size:
27.58 MB
Format:
Adobe Portable Document Format
Description:
Collections