銠金屬(I)/掌性雙環[2.2.1]雙烯配體催化進行不對稱1,4-加成反應:合成掌性γ-胺基酸及γ-胺基膦酸之應用

dc.contributor吳學亮zh_TW
dc.contributorWu, Hsyueh-Liangen_US
dc.contributor.author黃志浩zh_TW
dc.contributor.authorHuang, Chih-Haoen_US
dc.date.accessioned2019-09-04T09:07:11Z
dc.date.available不公開
dc.date.available2019-09-04T09:07:11Z
dc.date.issued2016
dc.description.abstract本論文研究主題為利用本實驗室所開發的掌性雙環[2.2.1]雙烯配體與一價銠金屬形成之催化劑催化芳香基硼酸與γ-位胺基及膦酸酯取代之α , β-不飽和酯類進行不對稱1,4-加成反應。使用三莫耳百分率的銠金屬試劑(3 mol% of Rh)及L1e或L1f配體催化加成反應進行,生成的產物其產率有26–>99%,鏡像超越值為90–>99.5% ee。這個合成方法可利用來合成balcofen及phaclofen藥物分子。zh_TW
dc.description.abstractThis thesis describes an efficient synthesis of highly enantioenriched 4-amino-3-aryl-butanoates and 4-phosphoryl-3-aryl-butanoates via an enantioselective 1,4-addition of an array of aryboronic acids to γ-amino-α , β-unsaturated esters and γ-phosphoryl-α , β-unsaturated esters. In the presence of 3 mol% of the Rh(I)/ chiral diene L1e or L1f as catalyst, the conjugate addition adducts were isolated in 26–>99% yield and 90–>99.5% ee. The synthetic usefulness of the developed method was demonstrated in the syntheses of baclofen and phalcofen.en_US
dc.description.sponsorship化學系zh_TW
dc.identifierG060342041S
dc.identifier.urihttp://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22G060342041S%22.&%22.id.&
dc.identifier.urihttp://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/100051
dc.language中文
dc.subject銠金屬催化試劑zh_TW
dc.subject掌性雙烯配基zh_TW
dc.subjectαzh_TW
dc.subjectβ-不飽和羧酸酯zh_TW
dc.subjectRhodiumen_US
dc.subjectChiral diene liganden_US
dc.subjectαen_US
dc.subjectβ-Unsaturated estersen_US
dc.title銠金屬(I)/掌性雙環[2.2.1]雙烯配體催化進行不對稱1,4-加成反應:合成掌性γ-胺基酸及γ-胺基膦酸之應用zh_TW
dc.titleEnantioselective Synthesis of γ-Amino Acids and γ-Amino Phosphonic Acids via Rhodium Catalyzed Asymmetric 1,4-Conjugate Addition Reactionsen_US

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