銠金屬(I)/掌性雙環[2.2.1]雙烯配體催化進行不對稱1,4-加成反應:合成掌性γ-胺基酸及γ-胺基膦酸之應用
dc.contributor | 吳學亮 | zh_TW |
dc.contributor | Wu, Hsyueh-Liang | en_US |
dc.contributor.author | 黃志浩 | zh_TW |
dc.contributor.author | Huang, Chih-Hao | en_US |
dc.date.accessioned | 2019-09-04T09:07:11Z | |
dc.date.available | 不公開 | |
dc.date.available | 2019-09-04T09:07:11Z | |
dc.date.issued | 2016 | |
dc.description.abstract | 本論文研究主題為利用本實驗室所開發的掌性雙環[2.2.1]雙烯配體與一價銠金屬形成之催化劑催化芳香基硼酸與γ-位胺基及膦酸酯取代之α , β-不飽和酯類進行不對稱1,4-加成反應。使用三莫耳百分率的銠金屬試劑(3 mol% of Rh)及L1e或L1f配體催化加成反應進行,生成的產物其產率有26–>99%,鏡像超越值為90–>99.5% ee。這個合成方法可利用來合成balcofen及phaclofen藥物分子。 | zh_TW |
dc.description.abstract | This thesis describes an efficient synthesis of highly enantioenriched 4-amino-3-aryl-butanoates and 4-phosphoryl-3-aryl-butanoates via an enantioselective 1,4-addition of an array of aryboronic acids to γ-amino-α , β-unsaturated esters and γ-phosphoryl-α , β-unsaturated esters. In the presence of 3 mol% of the Rh(I)/ chiral diene L1e or L1f as catalyst, the conjugate addition adducts were isolated in 26–>99% yield and 90–>99.5% ee. The synthetic usefulness of the developed method was demonstrated in the syntheses of baclofen and phalcofen. | en_US |
dc.description.sponsorship | 化學系 | zh_TW |
dc.identifier | G060342041S | |
dc.identifier.uri | http://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22G060342041S%22.&%22.id.& | |
dc.identifier.uri | http://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/100051 | |
dc.language | 中文 | |
dc.subject | 銠金屬催化試劑 | zh_TW |
dc.subject | 掌性雙烯配基 | zh_TW |
dc.subject | α | zh_TW |
dc.subject | β-不飽和羧酸酯 | zh_TW |
dc.subject | Rhodium | en_US |
dc.subject | Chiral diene ligand | en_US |
dc.subject | α | en_US |
dc.subject | β-Unsaturated esters | en_US |
dc.title | 銠金屬(I)/掌性雙環[2.2.1]雙烯配體催化進行不對稱1,4-加成反應:合成掌性γ-胺基酸及γ-胺基膦酸之應用 | zh_TW |
dc.title | Enantioselective Synthesis of γ-Amino Acids and γ-Amino Phosphonic Acids via Rhodium Catalyzed Asymmetric 1,4-Conjugate Addition Reactions | en_US |