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Title: 人類非小細肺癌細胞轉殖 p21Cip1/WAF1 促進玫瑰樹鹼的凋亡效應
Other Titles: Ellipticine-induced Apoptosis in Human Non-small Cell Lung Cancer Cells with Ectopic Expression of p21Cip1/WAF1  
Authors: 林佳薇
Issue Date: Dec-2007
Publisher: 國立臺灣師範大學生命科學學系
Department of Life Science, NTNU
Abstract: 轉殖p53所調控的下游基因p21□(p21)至p53突變非小細肺癌細胞株H1437,將穩定成長之細胞以topoisomerase Ⅱ抑制劑ellipticine處理後,其敏感率會增加,這個改變,是因為所細胞凋亡增加所致。因此未來可以發展藉外源性p21基因,增加對p53突變的癌細胞的藥物敏感性。
Topoisomerase II inhibitor ellipticine-induced apoptosis in human non-small cell lung cancer cells H1437 with ectopic expression of p21□ (p21), that is distinct from the parental cells that are drug resistant. The enhanced cytotoxic effect can be achieved through apoptosis. The results indicated that the sensitivity of ellipticine in p53-mutated NSCLC cells can be enhanced through introduction and nuclear migration of downstream of p53 regulator, p21.
Other Identifiers: 12ED579C-BE1F-944B-0317-5FE309761424
Appears in Collections:生物學報

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