人類非小細肺癌細胞轉殖 p21Cip1/WAF1 促進玫瑰樹鹼的凋亡效應

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dc.contributor.author林佳薇zh_tw
dc.contributor.author林銘儀zh_tw
dc.contributor.author路淑怡zh_tw
dc.contributor.author黃慧滇zh_tw
dc.contributor.author方剛zh_tw
dc.date.accessioned2014-10-27T15:00:54Z
dc.date.available2014-10-27T15:00:54Z
dc.date.issued2007-12-??zh_TW
dc.description.abstract轉殖p53所調控的下游基因p21□(p21)至p53突變非小細肺癌細胞株H1437，將穩定成長之細胞以topoisomerase Ⅱ抑制劑ellipticine處理後，其敏感率會增加，這個改變，是因為所細胞凋亡增加所致。因此未來可以發展藉外源性p21基因，增加對p53突變的癌細胞的藥物敏感性。zh_tw
dc.description.abstractTopoisomerase II inhibitor ellipticine-induced apoptosis in human non-small cell lung cancer cells H1437 with ectopic expression of p21□ (p21), that is distinct from the parental cells that are drug resistant. The enhanced cytotoxic effect can be achieved through apoptosis. The results indicated that the sensitivity of ellipticine in p53-mutated NSCLC cells can be enhanced through introduction and nuclear migration of downstream of p53 regulator, p21.en_US
dc.identifier12ED579C-BE1F-944B-0317-5FE309761424zh_TW
dc.identifier.urihttp://rportal.lib.ntnu.edu.tw/handle/20.500.12235/6736
dc.language中文zh_TW
dc.publisher國立臺灣師範大學生命科學學系zh_tw
dc.publisherDepartment of Life Science, NTNUen_US
dc.relation42(2)，99-104zh_TW
dc.relation.ispartof生物學報zh_tw
dc.subject.other人類非小細肺癌細胞zh_tw
dc.subject.other玫瑰樹鹼zh_tw
dc.subject.other凋亡zh_tw
dc.subject.otherHuman non-small cell lung cancer cellsen_US
dc.subject.otherEllipticineen_US
dc.subject.otherApoptosisen_US
dc.title人類非小細肺癌細胞轉殖 p21Cip1/WAF1 促進玫瑰樹鹼的凋亡效應zh-tw
dc.title.alternativeEllipticine-induced Apoptosis in Human Non-small Cell Lung Cancer Cells with Ectopic Expression of p21Cip1/WAF1  zh_tw

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