人類非小細肺癌細胞轉殖 p21Cip1/WAF1 促進玫瑰樹鹼的凋亡效應

dc.contributor.author 林佳薇 zh_tw
dc.contributor.author 林銘儀 zh_tw
dc.contributor.author 路淑怡 zh_tw
dc.contributor.author 黃慧滇 zh_tw
dc.contributor.author 方剛 zh_tw
dc.date.accessioned 2014-10-27T15:00:54Z
dc.date.available 2014-10-27T15:00:54Z
dc.date.issued 2007-12-?? zh_TW
dc.description.abstract 轉殖p53所調控的下游基因p21□(p21)至p53突變非小細肺癌細胞株H1437,將穩定成長之細胞以topoisomerase Ⅱ抑制劑ellipticine處理後,其敏感率會增加,這個改變,是因為所細胞凋亡增加所致。因此未來可以發展藉外源性p21基因,增加對p53突變的癌細胞的藥物敏感性。 zh_tw
dc.description.abstract Topoisomerase II inhibitor ellipticine-induced apoptosis in human non-small cell lung cancer cells H1437 with ectopic expression of p21□ (p21), that is distinct from the parental cells that are drug resistant. The enhanced cytotoxic effect can be achieved through apoptosis. The results indicated that the sensitivity of ellipticine in p53-mutated NSCLC cells can be enhanced through introduction and nuclear migration of downstream of p53 regulator, p21. en_US
dc.identifier 12ED579C-BE1F-944B-0317-5FE309761424 zh_TW
dc.identifier.uri http://rportal.lib.ntnu.edu.tw/handle/20.500.12235/6736
dc.language 中文 zh_TW
dc.publisher 國立臺灣師範大學生命科學學系 zh_tw
dc.publisher Department of Life Science, NTNU en_US
dc.relation 42(2),99-104 zh_TW
dc.relation.ispartof 生物學報 zh_tw
dc.subject.other 人類非小細肺癌細胞 zh_tw
dc.subject.other 玫瑰樹鹼 zh_tw
dc.subject.other 凋亡 zh_tw
dc.subject.other Human non-small cell lung cancer cells en_US
dc.subject.other Ellipticine en_US
dc.subject.other Apoptosis en_US
dc.title 人類非小細肺癌細胞轉殖 p21Cip1/WAF1 促進玫瑰樹鹼的凋亡效應 zh-tw
dc.title.alternative Ellipticine-induced Apoptosis in Human Non-small Cell Lung Cancer Cells with Ectopic Expression of p21Cip1/WAF1   zh_tw
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