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dc.contributor.authorT.-R. Kuoen_US
dc.contributor.authorC.-T. Hsuen_US
dc.contributor.authorW. Loen_US
dc.contributor.authorS.-J. Chiangen_US
dc.contributor.authorS.-J. Linen_US
dc.contributor.authorC.-Y. Dongen_US
dc.contributor.authorChia-Chun Chenen_US
dc.description.abstractThe overlapping wavelength of photoluminescence (PL) of zinc oxide nanoparticles (ZnO NPs) and autofluorescence (AF) from the stratum corneum (SC) has for a long time held back researchers from investigating the chemically enhanced penetration pathways of ZnO NPs into the SC lipids. However, the non-linear polarization effect of second harmonic generation (SHG) may be used for ZnO NPs to be distinguished from the AF of the SC. This study combined the SHG of ZnO NPs and the AF of the SC to image the transdermal delivery of ZnO NPs under the chemical enhancer conditions of oleic acid (OA), ethanol (EtOH) and oleic acid-ethanol (OA-EtOH). In addition to qualitative imaging, the microtransport properties of ZnO NPs were quantified to give the enhancements of the vehicle-to-skin partition coefficient (K), the SHG intensity gradient (G) and the effective diffusion path length (L). The results showed that OA, EtOH and OA-EtOH were all capable of enhancing the transdermal delivery of ZnO NPs by increasing the intercellular lipid fluidity or extracting lipids from the SC.en_US
dc.relationBiomaterials, 30(16), 3002-3008.en_US
dc.subject.otherTwo-photon microscopyen_US
dc.subject.otherSecond harmonic generationen_US
dc.subject.otherZnO nanoparticlesen_US
dc.subject.otherChemical enhanceren_US
dc.titleChemical Enhancer Induced Changes in the Mechanisms of Transdermal Delivery of Zinc Oxide Nanoparticlesen_US
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