Chemical Enhancer Induced Changes in the Mechanisms of Transdermal Delivery of Zinc Oxide Nanoparticles

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dc.contributor國立臺灣師範大學化學系zh_tw
dc.contributor.authorT.-R. Kuoen_US
dc.contributor.authorC.-L.Wuen_US
dc.contributor.authorC.-T. Hsuen_US
dc.contributor.authorW. Loen_US
dc.contributor.authorS.-J. Chiangen_US
dc.contributor.authorS.-J. Linen_US
dc.contributor.authorC.-Y. Dongen_US
dc.contributor.authorChia-Chun Chenen_US
dc.date.accessioned2014-12-02T06:41:35Z
dc.date.available2014-12-02T06:41:35Z
dc.date.issued2009-06-01zh_TW
dc.description.abstractThe overlapping wavelength of photoluminescence (PL) of zinc oxide nanoparticles (ZnO NPs) and autofluorescence (AF) from the stratum corneum (SC) has for a long time held back researchers from investigating the chemically enhanced penetration pathways of ZnO NPs into the SC lipids. However, the non-linear polarization effect of second harmonic generation (SHG) may be used for ZnO NPs to be distinguished from the AF of the SC. This study combined the SHG of ZnO NPs and the AF of the SC to image the transdermal delivery of ZnO NPs under the chemical enhancer conditions of oleic acid (OA), ethanol (EtOH) and oleic acid-ethanol (OA-EtOH). In addition to qualitative imaging, the microtransport properties of ZnO NPs were quantified to give the enhancements of the vehicle-to-skin partition coefficient (K), the SHG intensity gradient (G) and the effective diffusion path length (L). The results showed that OA, EtOH and OA-EtOH were all capable of enhancing the transdermal delivery of ZnO NPs by increasing the intercellular lipid fluidity or extracting lipids from the SC.en_US
dc.description.urihttp://ac.els-cdn.com/S0142961209001240/1-s2.0-S0142961209001240-main.pdf?_tid=620e2cc6-b0cf-11e3-91a3-00000aacb361&acdnat=1395389230_cd8451c51a6382e3e429097ec59a4108zh_TW
dc.identifierntnulib_tp_C0301_01_058zh_TW
dc.identifier.issn0142-9612zh_TW
dc.identifier.urihttp://rportal.lib.ntnu.edu.tw/handle/20.500.12235/42342
dc.languageen_USzh_TW
dc.publisherElsevieren_US
dc.relationBiomaterials, 30(16), 3002-3008.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.biomaterials.2009.02.003zh_TW
dc.subject.otherTwo-photon microscopyen_US
dc.subject.otherSecond harmonic generationen_US
dc.subject.otherZnO nanoparticlesen_US
dc.subject.otherChemical enhanceren_US
dc.subject.otherTransdermalen_US
dc.titleChemical Enhancer Induced Changes in the Mechanisms of Transdermal Delivery of Zinc Oxide Nanoparticlesen_US

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