教師著作

Permanent URI for this collectionhttp://rportal.lib.ntnu.edu.tw/handle/20.500.12235/37076

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Author: search.filters.author.C.-T. ChenHas files: No

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    Direct evidence of type II band alignment in nanoscale P3HT/CdSe heterostructures
    (IOP Publishing, 2011-02-11) C.-H. Wang; C.-W. Chen; Y.-T. Chen; C.-T. Chen; Y.-F.Chen; S.-W. Chou; Chia-Chun Chen
    Due to inherent advantages of both constituent materials, organic/inorganic hybrid composites have attracted increasing attention. One of the fundamental issues needed to be resolved is their band alignment, which governs most of the electrical and optical properties. Here, we report the investigation of optical transition in poly(3-hexylthiophene) (P3HT)/CdSe nano-composites (NCs). It is found that the relaxation dynamics of photo-carriers in NCs is dominated by charge separation effects. Based on the band bending effect and the quantum confinement energy of electrons in the conduction band of CdSe quantum dots, we provide direct evidence of type II band alignment in P3HT/CdSe NCs. The establishment of a type II transition in NCs is very useful for the future design of efficient optoelectronic devices based on conjugated polymer/semiconductor hybrid systems.
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    A Triantennary Dendritic Galactoside-Capped Nanohybrid with a ZnS/CdSe Nanoparticle Core as a Hydrophilic, Fluorescent, Multivalent Probe for Metastatic Lung Cancer Cells
    (Wiley-VCH Verlag, 2008-02-22) C.-T. Chen; Y.-S. Munot; S.-B. Salunke; Y.-C. Wang; R.-K. Lin; C.-C. Lin; Chia-Chun Chen; Y-H. Liu
    A new tri-antennary, galactoside-capped gallamide dendritic anchor with thiolate focal group is synthesized via click chemistry. The highly hydrophilic dendron was efficiently anchored onto the surface of CdSe/ZnS core/shell nanoparticles in a covalent fashion, as evidenced by 1H NMR spectrum of the resultant nanohybrid with intact core fluorescent property. The water-soluble nano-hybrid was found smoothly and selectively uptaken by lung cancer cells enriched with membrane-bound asialoprotein receptors in 2–3 h, as evidenced by confocal microscopic analysis. Furthermore, cancer cells that are undergoing active mitosis also tend to uptake the nanohybrids efficiently and remain sustainable in serum-containing medium for several days, which shed light on its application as a photodynamic drug carrier for apoptosis study.
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    Globotriose-Functionalized Gold Nanoparticles as Multivalent Probes for Shiga-like Toxin
    (Wiley-VCH Verlag, 2008-05-05) Y.-Y. Chien; M.-D. Jan; A.-K. Adak; H.-C. Tzeng; Y.-P. Lin; Y.-J. Chen; K.-T. Wang; C.-T. Chen; Chia-Chun Chen; C.-C. Lin
    Compared to monovalent carbohydrates, multivalent carbohydrate ligands exhibit significantly enhanced binding affinities to their interacting proteins. Here, we report globotriose (Pk ligand)-functionalized gold nanoparticle (AuNP) probes for the investigation of multivalent interactions with the B5 subunit of Shiga-like toxin I (B-Slt). Six Pk-ligand-encapsulated AuNPs (Pk-AuNPs) of varying particle size and linker length were synthesized and evaluated for their potential as multivalent affinity probes by using a surface plasmon resonance competition assay. The affinity of these probes for the interacting proteins was greatly affected by nanoparticle size, linker length, and ligand density on nanoparticle surface. For example, the 20-nm 20-Pk-l-AuNP, which had a relatively long linker showed a >108-fold increase in affinity compared with the mono Pk ligand. This intrinsic high-affinity AuNP probe specifically captured the recombinant B-Slt from Escherichia coli lysate, and the resulting purity of the B-Slt was >95 %. We also developed a robust Pk-AuNP-based detection method for Slt-I by combining the technique with silver enhancement.
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    Diethylene Glycol Ether-Linked 3, 4, 5,-Trihydroxybenzamides as Triple Branched Dendritic Anchors to CdSe/ZnS Core/Shell Type Nanoparticles: Potential Hydrophilic Fluorescent Probes
    (Royal Society of Chemistry, 2005-05-21) C.-T. Chen; V.-D. Pawar; Y.-S. Munot; Chia-Chun Chen; C.-R. Hsu
    Functionalized N-2-mercaptoethyl-gallamides bearing three or five hydroxyl units that are tethered with diethylene glycol ether(s) allow for transferring hydrophobically pyridine-capped CdSe/ZnS core/shell nanoparticles from an organic to an aqueous layer with intact fluorescent profiles.