屏面掃描式三維光學同調斷層造影系統之設計與架設

Abstract

光學同調斷層攝影術(Optical Coherence Tomography；OCT)是一種基於低同調干涉儀原理的造影技術，自1991年被提出以來，已經成為一個能提供非接觸式與高速斷層影像的有利工具。藉由搭配寬頻近紅外光源的使用，OCT可在數釐米的穿透深度範圍內具有10到30微米的空間解析力。在本研究中，我們設計並架設一套屏面掃描式三維光學同調斷層造影系統:以超高亮度發光二極體為光源，搭配聲光調變器產生並偵測外差干涉訊號。以此自行建立的架構下，我們可以高速掃描鏡子產生大面積屏面掃描影像，最後藉由多張二維屏片影像重組出三維立體影像，可用來完整描述待測物體的結構而不會遺漏掉任何有用的資訊。

Since its introduction in 1991, optical coherence tomography (OCT), based on low coherence interferometry, has been used as a powerful tool to support non-contact and high-speed tomographic images. By using broadband near-infrared light sources, OCT achieves resolutions of 10 to 30 m with depth penetrations of the order of a few milimeters. In this research, we designed and construct an en-face three-dimensional (3D) OCT system: a superluminescent diode is used as a light source in combination with acousto-optic modulators for heterodyne signal generation and detection. With our setup we are able to scan en-face areas by using a resonant scanning mirror. After reconstruction of several 2D sections, 3D OCT image can fully describe the 3D morphology of samples under study, no structural details are missed.