Multiple Release Kinetics of Targeted Drug from Gold Nanorod Embedded Polyelectrolyte Conjugates Induced by Near-infrared Laser Irradiation.

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dc.contributor國立臺灣師範大學化學系zh_tw
dc.contributor.authorT.-R. Kuoen_US
dc.contributor.authorV.-A. Hovhannisyanen_US
dc.contributor.authorY.-C. Chaoen_US
dc.contributor.authorS.-L. Chaoen_US
dc.contributor.authorS.-J. Chiangen_US
dc.contributor.authorS.-J. Linen_US
dc.contributor.authorC.-Y. Dongen_US
dc.contributor.authorChia-Chun Chenen_US
dc.date.accessioned2014-12-02T06:41:36Z
dc.date.available2014-12-02T06:41:36Z
dc.date.issued2010-10-13zh_TW
dc.description.abstractThe conjugates of gold nanorods and the model drug, fluorescein isothiocyanate (FITC), embedded inside polyelectrolytes (GNRs/FITC@PLE) were synthesized to study the release kinetics of FITC under femtosecond near-infrared (NIR) laser irradiation. The optical and structural properties of GNRs/FITC@PLE conjugates before and after laser treatments were examined using UV-vis spectroscopy, confocal microscopy, and transmission electron microscopy (TEM). The release of FITC from the conjugates was induced by the heat generated from gold nanorods under laser irradiation. The concentration of released FITC was measured as the time of continuous and periodic laser irradiation was varied. Within 5 min of the laser exposure, the release rates of FITC exhibited zero-order and first-order kinetics under continuous and periodic irradiation, respectively. Furthermore, a drug release system was designed based on the conjugates of gold nanorods and the anticancer drug, paclitaxel (PTX), embedded inside polyelectrolytes (GNRs/PTX@PLE). The conjugates were applied for in vitro studies with breast cancer cells. The release of PTX from the conjugates was triggered by NIR laser irradiation, and the inhibition rates of the cells showed strong dependencies on the irradiation modes and time. The results suggested that the multiple releases of PTX from the conjugates can be controlled by laser irradiation within a long period of time. Our system holds great potential for future therapeutic applications on breast cancers.en_US
dc.description.urihttp://pubs.acs.org/doi/pdf/10.1021/ja105360zzh_TW
dc.identifierntnulib_tp_C0301_01_067zh_TW
dc.identifier.issn0002-7863zh_TW
dc.identifier.urihttp://rportal.lib.ntnu.edu.tw/handle/20.500.12235/42351
dc.languageen_USzh_TW
dc.publisherAmerican Chemical Societyen_US
dc.relationJournal of the American Chemical Society, 132(40), 14163-14171.en_US
dc.relation.urihttp://dx.doi.org/10.1021/ja105360z.zh_TW
dc.titleMultiple Release Kinetics of Targeted Drug from Gold Nanorod Embedded Polyelectrolyte Conjugates Induced by Near-infrared Laser Irradiation.en_US

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