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The Effect of Multiple Exercise Training on DHEA-S Level and Physical Fitness of the Community-Dwelling Elderly
|Abstract:||老化會導致肌力喪失而影響體適能，而運動配合口服硫鹽化脫氫異雄固酮(Dehydroepiandrosterone sulfate, DHEA-S)可增進肌力，然運動訓練對於內生性DHEA-S之影響以及DHEA-S與運動效果之關聯性仍未清楚，本研究欲瞭解老年人於多元運動訓練後DHEA-S的改變，以及體適能之增進與內生性DHEA-S的關聯性。本研究量測24位社區老人（年齡71.50±0.90歲，身體質量指數為25.50±0.70kg/平方公尺）於16週多元運動前後之DHEA-S濃度與體適能包括身體組成（肌肉重、肌肉百分比、脂肪重和體脂肪百分比）、功能性肌力（手握力和功能性下肢肌力）、心肺適能以及平衡能力。結果發現DHEA-S於運動訓練後顯著提升（3.98±1.27ng/ml提高至9.14±1.86ng/ml，p=.027），肌肉百分比、脂肪重和體脂肪百分比分別顯著提高和降低(p<.0001)；左手握力由21.30±1.30公斤增加至23.20±1.50公斤(p=.032)，起站走時間由8.20±0.30秒減少至5.50±0.10秒(p<.0001)；睜眼和閉眼單足站立時間均顯著增加(p<.05)，而聲光反應時間亦顯著增加(p<.05)；六分鐘走距離由448.40±12.00公尺顯著增加為482.30±11.70公尺(p=.001)，而DHEA-S濃度之改變量與大部份體適能量測之改變量之間不具相關性。這些結果顯示本研究之多元運動訓練方式可提升老年人之內生性DHEA-S濃度，減少脂肪量，同時增進功能性肌力、心肺適能和平衡能力，但DHEA-S濃度的改變幅度無法完全反應體適能增減幅度，其與運動訓練效果之關聯性仍需進一步探究。|
Aging induced loss of muscle power, which affects physical fitness and function. Exercise with oral DHEA-S had been demonstrated to improve muscle power of the elderly, while the effect of exercise training on endogenous DHEA-S and the association between DHEA-S and the exercise effect was unknown. Hence, this study was to investigate the changes in endogenous DHEA-S after exercise training and the association of the improvement in physical fitness after training and DHEA-S of the elderly. Twenty-four community-dwelling sedentary elderly (age=71.50�0.90 years, BMI=25.50�0.70 kg/m^2) were involved in 16-week multiple exercise training. DHEA-S and physical fitness including body composition (muscle mass, muscle percent, fat mass and fat percent), functional strength (grip and functional low extremity muscular power), cardiopulmonary fitness and balance ability were measured pre- and post-training. The results showed that DHEA-S level after training significantly increased (3.98�1.27 to 9.14�1.86 ng/ml, p=.027). Significant increase was noted in muscle percent and decrease in fat mass as well as fat percent (p<.0001). Left-hand grip increased from 21.30�1.30 to 23.20�1.50 kg (p=.032) and the time of 8-foot up-and-go test decreased from 8.20�0.30 to 5.50�0.10 sec (p<.0001). The time of both stand with eye-open and eye-close significantly increased (p<.05), while the reactive time to sound and light also increased (p<.05). The 6-min walk test significantly increased from 448.40�12.00 to 482.30�11.70 m (p=.001). No significant correlation was noted between the changes in DHEA-S and most measurements of physical fitness. These results showed that multiple exercise training in this study could enhance DHEA-S level, reduce fat content and improve functional strength, cardiopulmonary fitness and balance of the elderly. However, the change in DHEA-S level was unable to totally reflect the changes in physical fitness. Further investigation of the association of DHEA-S and the exercise effect was required.
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