教師著作
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Browsing 教師著作 by Subject "Anti-inflammation"
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Item Assessment of anticancer potential of several commonly used herbal seasonings by antioxidant and anti-inflammatory activities.(2004-10-30) Po-Jung Tsai, Hui-Hsin Chen and Su-Chen HoAnti-oxidant and anti-inflammatory activities are extensively used to screen chemopreventive foods. However, the real efficacies of these activities in evaluating anti-cancer potential remain unclear. Five well-known anti-cancer herbs, ginger, red pepper, garlic, green onion and leek, were selected and assessed in this study. Antioxidant function was evaluated based on the scavenging ability of the cation radical. Moreover, anti-inflammatory activity was determined based on inhibitory effect of nitric oxide (NO) production by lipopolysaccharide (LPS)-activated macrophages. The antioxidant activity of the five herbs followed the order: ginger> red pepper> leek> green onion and garlic. All of the subject herbs had a strict inhibitory effect on NO production. The anti-inflammatory activity could be ranked based on the IC50 of the herbs, as garlic> ginger> green onion> leek and red pepper. The anti-inflammatory activities of these five herbal seasonings reflect well with the anti-cancer potencies established by the national cancer institute of America. Thus, this study proposed that anti-inflammation was a better indicator than anti-oxidation for screening chemopreventive agents.Item In vitro antimicrobial and anti-inflammatory effects of herbs against Propionibacterium acnes(Elsevier, 2010-04-01) Tsai TH, Tsai TH, Wu WH, Tseng TP, Tsai PJPropionibacterium acnes play an important role in the pathogenesis of acne by inducing certain inflammatory mediators and comedogenesis. The objective of this study was to evaluate the antimicrobial and anti-inflammatory effects of herbal extracts against P. acnes. Among the ten tested herbs, methanolic extracts of rose (Rosa damascene), duzhong (Eucommia ulmoides Oliv.), and yerba mate (Ilex paraguariensis) were found to inhibit the growth of P. acnes with respective minimum inhibitory concentrations of 2, 0.5, and 1 mg/ml. In addition, duzhong and yerba mate extracts reduced the secretion of pro-inflammatory cytokines such as tumour necrosis factor-α, interleukin (IL)-8, and IL-1β by human monocytic THP-1 cells pretreated with heat-killed P. acnes at a concentration of 0.1 mg/ml. Our results suggested that duzhong and yerba mate extracts possess both antimicrobial and anti-inflammatory effects against P. acnes and can possibly be used as therapeutic agents for acne.Item In vitro antimicrobial and anti-inflammatory effects of herbs against Propionibacterium acnes.(ELSEVIER, 2010-04-01) Tsung-Hsien Tsai, Tzung-Hsun Tsai, Wen-Huey Wu, Jonathon Te-Peng Tseng and Po-Jung Tsai.,Propionibacterium acnes play an important role in the pathogenesis of acne by inducing certain inflammatory mediators and comedogenesis. The objective of this study was to evaluate the antimicrobial and anti-inflammatory effects of herbal extracts against P. acnes. Among the ten tested herbs, methanolic extracts of rose (Rosa damascene), duzhong (Eucommia ulmoides Oliv.), and yerba mate (Ilex paraguariensis) were found to inhibit the growth of P. acnes with respective minimum inhibitory concentrations of 2, 0.5, and 1 mg/ml. In addition, duzhong and yerba mate extracts reduced the secretion of pro-inflammatory cytokines such as tumour necrosis factor-α, interleukin (IL)-8, and IL-1β by human monocytic THP-1 cells pretreated with heat-killed P. acnes at a concentration of 0.1 mg/ml. Our results suggested that duzhong and yerba mate extracts possess both antimicrobial and anti-inflammatory effects against P. acnes and can possibly be used as therapeutic agents for acne.