磁性奈米粒子在動物體內代謝之研究
Abstract
（MNPS）的Fe3O4磁性納米粒子已廣泛應用於許多醫療領域，但很少有研究結果清楚地表明靜脈注射後的粒子。我們進行了磁檢查掃描：SQUID biosusceptometry（SSB）和非磁性考試進行壓縮的代謝靜脈MNP的研究。基於對SSB分析和成立於體外非磁性生物測定的結果，本研究提出了一個模型組成的流動電話號碼可攜性代謝的一種急性代謝階段的持續時間為8小時，其次是一種慢性代謝性階段，持續28天以下的流動電話號碼可攜服務注射。主要功能包括提供的MNP的心臟和其他器官，豐富的巨噬細胞的生物降解MNP的器官，鐵代謝物在尿中的排泄，並從肝，脾鐵負荷的恢復。血清轉鐵蛋白的水平和循環的紅血細胞的數目的增加，伴隨著增加，血清鐵水平以下的MNP注射。這些發現暗示的MNP的鐵的氧化，變廢為寶的新的血紅蛋白和紅細胞合成。
Magnetic nanoparticles (MNPs) of Fe3O4 have been widely applied in many medical fields, but few studies have clearly shown the outcome of particles following intravenous injection. We performed a magnetic examination using scanning SQUID biosusceptometry (SSB) and non-magnetic examinations for compressively studied the metabolism of intravenous MNPs. Based on the results of SSB analysis and those of established in vitro nonmagnetic bioassays, this study proposes a model of MNP metabolism consisting of an acute metabolic phase with an 8 h duration that is followed by a chronic metabolic phase that continues for 28 d following MNP injection. The major features included the delivery of the MNPs to the heart and other organs, the biodegradation of the MNPs in organs rich with macrophages, the excretion of iron metabolites in the urine, and the recovery of the iron load from the liver and the spleen. Increases in serum iron levels following MNPs injection were accompanied by increases in the level of transferrin in the serum and the number of circulating red blood cells. These finding implied the iron form degradation of MNPs were reutilized for new hemoglobin and red blood cells synthesis.
Magnetic nanoparticles (MNPs) of Fe3O4 have been widely applied in many medical fields, but few studies have clearly shown the outcome of particles following intravenous injection. We performed a magnetic examination using scanning SQUID biosusceptometry (SSB) and non-magnetic examinations for compressively studied the metabolism of intravenous MNPs. Based on the results of SSB analysis and those of established in vitro nonmagnetic bioassays, this study proposes a model of MNP metabolism consisting of an acute metabolic phase with an 8 h duration that is followed by a chronic metabolic phase that continues for 28 d following MNP injection. The major features included the delivery of the MNPs to the heart and other organs, the biodegradation of the MNPs in organs rich with macrophages, the excretion of iron metabolites in the urine, and the recovery of the iron load from the liver and the spleen. Increases in serum iron levels following MNPs injection were accompanied by increases in the level of transferrin in the serum and the number of circulating red blood cells. These finding implied the iron form degradation of MNPs were reutilized for new hemoglobin and red blood cells synthesis.
Description
Keywords
磁性納米粒子, 代謝