使用海洛因與安非他命之愛滋感染者在美沙冬與HAART之順從性研究
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2015
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Abstract
本研究之目的為了解藥癮愛滋感染者在美沙冬治療與雞尾酒療法之服藥順從情形，並探討美沙冬治療是否提升研究對象雞尾酒療法之順從性。本研究採用衛生福利部疾病管制署次級資料，分析2007-2012年之間感染愛滋病毒且發展出AIDS之藥癮者，並藉由卡方、t-test、二元羅吉斯回歸分析背景變項與HIV／AIDS事件的關係，此事件定義係依研究對象CD4高低分為兩組；而存活分析則解釋藥物組別(兩者皆參加、兩者皆未參加、僅參加美沙冬療法、僅參加雞尾酒療法)與HIV／AIDS感染天數之關係，該感染天數定義為自感染HIV至發展出AIDS之天數，最後分析美沙冬參與天數與美沙冬及雞尾酒療法服藥順從性之關係。
本研究共分析258人，結果顯示婚姻狀態與發展出HIV／AIDS有顯著差異；存活分析部分，HIV感染天數越長與不同藥物治療組別有相關，而參與美沙冬天數、美沙冬服藥順從性及雞尾酒療法服藥順從性有相關。本研究建議醫療院所相關人員應減少個案對於愛滋感染的疑慮以及增加個案對於藥癮問題的認識，此外當個案對於美沙冬有所疑慮時應立即給予釐清，並且給予個案正向鼓勵以增強其服藥順從性。
In this study is examine whether methadone maintenance therapy (MMT) increased highly active antiretroviral therapy (HAART) adherence among a cohort of HIV-infected injection drug users (IDUs) and who is develop AIDS . We obtained demographic, MMT and HAART taking history from the Taiwan Centers for Disease Control (Taiwan CDC). There were 258 IDUs participants who accessed MMT from 2007-2012. We using Cox proportional hazards regression to examine the independent associations between MMT taking days and the HAART adherence; MMT adherence. Our finding is engagement in MMT was positively associated with HAART adherence (b=0.006, 95% CI: 1.001-1.010, p<.05), but negatively associated with MMT adherence (b=-0.33, 95% CI: 9.57-.978, p<.001). These results is that engagement in MMT can benefit against ART discontinuation. We suggestion the medical institutions personnel give IDUs encouragement to enhance medication adherence.
In this study is examine whether methadone maintenance therapy (MMT) increased highly active antiretroviral therapy (HAART) adherence among a cohort of HIV-infected injection drug users (IDUs) and who is develop AIDS . We obtained demographic, MMT and HAART taking history from the Taiwan Centers for Disease Control (Taiwan CDC). There were 258 IDUs participants who accessed MMT from 2007-2012. We using Cox proportional hazards regression to examine the independent associations between MMT taking days and the HAART adherence; MMT adherence. Our finding is engagement in MMT was positively associated with HAART adherence (b=0.006, 95% CI: 1.001-1.010, p<.05), but negatively associated with MMT adherence (b=-0.33, 95% CI: 9.57-.978, p<.001). These results is that engagement in MMT can benefit against ART discontinuation. We suggestion the medical institutions personnel give IDUs encouragement to enhance medication adherence.
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存活分析, 美沙冬療法, 服藥順從性, 雞尾酒療法, 藥癮愛滋感染者, Highly active antiretroviral therapy, Injecting-drug users, Medical adherence, Methadone maintenance therapy, Survival analysis