VP-16調控Akt-Ser473去磷酸化效應誘導p53突變非小細肺癌細胞的凋亡

dc.contributor.author 林佳薇 zh_tw
dc.contributor.author 林銘儀 zh_tw
dc.contributor.author 吳忠信 zh_tw
dc.contributor.author 黃慧滇 zh_tw
dc.contributor.author 方剛 zh_tw
dc.date.accessioned 2016-05-04T05:06:16Z
dc.date.available 2016-05-04T05:06:16Z
dc.date.issued 2008-06-??
dc.description.abstract 本文藉轉殖突變及野生型p53至該基因缺失非小細肺癌細胞株H1299,將穩定成長之細胞以topoisomerase Ⅱ抑制劑VP-16處理後,含有突變型p53於VP-16處理之後,細胞的凋亡會增加,但外源的野生型p53,卻不會讓VP-16啟動細胞凋亡,而前者是因為pAkt-Ser□去磷酸化所致,而外源野生型p53,卻不會讓pAkt-Ser□去磷酸化。因此可以推斷,VP-16對癌細胞的凋亡的生成與Akt去磷酸化與否有關,抑制Akt去磷酸化,降低VP-16所引發的細胞凋亡。 zh_tw
dc.identifier 499466AC-7D31-C822-F15F-FFB46A229F7A
dc.identifier.uri http://rportal.lib.ntnu.edu.tw/handle/20.500.12235/77992
dc.language 中文
dc.publisher 國立臺灣師範大學生命科學學系 zh_tw
dc.publisher Department of Life Science, NTNU en_US
dc.relation 43(1),17-24
dc.relation.ispartof 生物學報 zh_tw
dc.subject.other 人類非小細肺癌 zh_tw
dc.subject.other 細胞凋亡 zh_tw
dc.subject.other VP-16 en_US
dc.subject.other Akt en_US
dc.subject.other Human non-small cell lung cancer en_US
dc.subject.other Apoptosis en_US
dc.title VP-16調控Akt-Ser473去磷酸化效應誘導p53突變非小細肺癌細胞的凋亡 zh-tw
dc.title.alternative VP-16-mediated Akt-Ser473 Dephosphorylation Induces Apoptosis in Human Non-small Cell Lung Cancer Cells with Mutated p53 zh_tw
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