VP-16調控Akt-Ser473去磷酸化效應誘導p53突變非小細肺癌細胞的凋亡

Simple item page
dc.contributor.author林佳薇zh_tw
dc.contributor.author林銘儀zh_tw
dc.contributor.author吳忠信zh_tw
dc.contributor.author黃慧滇zh_tw
dc.contributor.author方剛zh_tw
dc.date.accessioned2014-10-27T15:01:14Z
dc.date.available2014-10-27T15:01:14Z
dc.date.issued2008-06-??zh_TW
dc.description.abstract本文藉轉殖突變及野生型p53至該基因缺失非小細肺癌細胞株H1299，將穩定成長之細胞以topoisomerase Ⅱ抑制劑VP-16處理後，含有突變型p53於VP-16處理之後，細胞的凋亡會增加，但外源的野生型p53，卻不會讓VP-16啟動細胞凋亡，而前者是因為pAkt-Ser□去磷酸化所致，而外源野生型p53，卻不會讓pAkt-Ser□去磷酸化。因此可以推斷，VP-16對癌細胞的凋亡的生成與Akt去磷酸化與否有關，抑制Akt去磷酸化，降低VP-16所引發的細胞凋亡。zh_tw
dc.identifier499466AC-7D31-C822-F15F-FFB46A229F7Azh_TW
dc.identifier.urihttp://rportal.lib.ntnu.edu.tw/handle/20.500.12235/6838
dc.language中文zh_TW
dc.publisher國立臺灣師範大學生命科學學系zh_tw
dc.publisherDepartment of Life Science, NTNUen_US
dc.relation43(1)，17-24zh_TW
dc.relation.ispartof生物學報zh_tw
dc.subject.other人類非小細肺癌zh_tw
dc.subject.other細胞凋亡zh_tw
dc.subject.otherVP-16en_US
dc.subject.otherAkten_US
dc.subject.otherHuman non-small cell lung canceren_US
dc.subject.otherApoptosisen_US
dc.titleVP-16調控Akt-Ser473去磷酸化效應誘導p53突變非小細肺癌細胞的凋亡zh-tw
dc.title.alternativeVP-16-mediated Akt-Ser473 Dephosphorylation Induces Apoptosis in Human Non-small Cell Lung Cancer Cells with Mutated p53zh_tw

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ntnulib_ja_C0401_4301_017.pdf
Size:
618.68 KB
Format:
Adobe Portable Document Format
Download

Collections

生物學報